Group:MUZIC:Plectin: Difference between revisions
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== Sequence annotation == | == Sequence annotation == | ||
Plectin can be divided in three main sections; a central coiled-coil rod domain, N and C-terminal globular region and exhibits a dumbbell like structure. C-terminal region is composed of 6 homologous repeating domains, and this region has a role in binding to intermediate filaments such as vimentin and cytokeratin <ref>PMID:3430617</ref>. N-terminal globular region contains actin binding domain | Plectin can be divided in three main sections; a central coiled-coil rod domain, N and C-terminal globular region and exhibits a dumbbell like structure. C-terminal region(2,828-4,684 aa) is composed of 6 homologous repeating domains, and this region has a role in binding to intermediate filaments such as vimentin and cytokeratin <ref>PMID:3430617</ref>. N-terminal globular region contains actin binding domain comprising two calponin homology(180-396 aa) and spectrin-like repeats(659-944 aa). | ||
[[Image:plectin.jpg]] | [[Image:plectin.jpg]] | ||
