1zpr: Difference between revisions

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[[Image:1zpr.jpg|left|200px]]<br /><applet load="1zpr" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1zpr.jpg|left|200px]]
caption="1zpr, resolution 2.5&Aring;" />
 
'''E. COLI THYMIDYLATE SYNTHASE MUTANT E58Q IN COMPLEX WITH CB3717 AND 2'-DEOXYURIDINE 5'-MONOPHOSPHATE (DUMP)'''<br />
{{Structure
|PDB= 1zpr |SIZE=350|CAPTION= <scene name='initialview01'>1zpr</scene>, resolution 2.5&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=UMP:2'-DEOXYURIDINE+5'-MONOPHOSPHATE'>UMP</scene> and <scene name='pdbligand=CB3:10-PROPARGYL-5,8-DIDEAZAFOLIC ACID'>CB3</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Thymidylate_synthase Thymidylate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.45 2.1.1.45]
|GENE=
}}
 
'''E. COLI THYMIDYLATE SYNTHASE MUTANT E58Q IN COMPLEX WITH CB3717 AND 2'-DEOXYURIDINE 5'-MONOPHOSPHATE (DUMP)'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1ZPR is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with <scene name='pdbligand=UMP:'>UMP</scene> and <scene name='pdbligand=CB3:'>CB3</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Thymidylate_synthase Thymidylate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.45 2.1.1.45] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZPR OCA].  
1ZPR is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZPR OCA].  


==Reference==
==Reference==
An essential role for water in an enzyme reaction mechanism: the crystal structure of the thymidylate synthase mutant E58Q., Sage CR, Rutenber EE, Stout TJ, Stroud RM, Biochemistry. 1996 Dec 17;35(50):16270-81. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8973201 8973201]
An essential role for water in an enzyme reaction mechanism: the crystal structure of the thymidylate synthase mutant E58Q., Sage CR, Rutenber EE, Stout TJ, Stroud RM, Biochemistry. 1996 Dec 17;35(50):16270-81. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8973201 8973201]
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: transferase]]
[[Category: transferase]]


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