3eui: Difference between revisions
From Proteopedia
Jump to navigationJump to search
m Protected "3eui" [edit=sysop:move=sysop] |
No edit summary |
||
| Line 1: | Line 1: | ||
[[ | ==A bimolecular anti-parallel-stranded Oxytricha nova telomeric quadruplex in complex with a 3,6-disubstituted acridine BSU-6042 in a large unit cell== | ||
<StructureSection load='3eui' size='340' side='right' caption='[[3eui]], [[Resolution|resolution]] 2.20Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3eui]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EUI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3EUI FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=NC5:3-[(2R)-2-ETHYLPIPERIDIN-1-YL]-N-[6-({3-[(2S)-2-ETHYLPIPERIDIN-1-YL]PROPANOYL}AMINO)ACRIDIN-3-YL]PROPANAMIDE'>NC5</scene>, <scene name='pdbligand=NCI:3,6-BIS{3-[(2R)-(2-ETHYLPIPERIDINO)]PROPIONAMIDO}ACRIDINE'>NCI</scene>, <scene name='pdbligand=SPM:SPERMINE'>SPM</scene></td></tr> | |||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1l1h|1l1h]], [[1jpq|1jpq]], [[1jrn|1jrn]], [[3ce5|3ce5]], [[3em2|3em2]], [[3eqw|3eqw]], [[3eru|3eru]], [[3es0|3es0]], [[3et8|3et8]], [[3eum|3eum]]</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3eui FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eui OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3eui RCSB], [http://www.ebi.ac.uk/pdbsum/3eui PDBsum]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
A series of disubstituted acridine ligands have been cocrystallized with a bimolecular DNA G-quadruplex. The ligands have a range of cyclic amino end groups of varying size. The crystal structures show that the diagonal loop in this quadruplex results in a large cavity for these groups, in contrast to the steric constraints imposed by propeller loops in human telomeric quadruplexes. We conclude that the nature of the loop has a significant influence on ligand selectivity for particular quadruplex folds. | |||
Selectivity in Ligand Recognition of G-Quadruplex Loops (dagger).,Campbell NH, Patel M, Tofa AB, Ghosh R, Parkinson GN, Neidle S Biochemistry. 2009 Feb 4. PMID:19173611<ref>PMID:19173611</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Campbell, N H]] | |||
== | [[Category: Neidle, S]] | ||
< | [[Category: Parkinson, G]] | ||
[[Category: Campbell, N H | |||
[[Category: Neidle, S | |||
[[Category: Parkinson, G | |||
[[Category: Anti-parallel]] | [[Category: Anti-parallel]] | ||
[[Category: Bimolecular]] | [[Category: Bimolecular]] | ||
Revision as of 08:37, 26 November 2014
A bimolecular anti-parallel-stranded Oxytricha nova telomeric quadruplex in complex with a 3,6-disubstituted acridine BSU-6042 in a large unit cell
| ||||||||||||
