3esk: Difference between revisions
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{{STRUCTURE_3esk| PDB=3esk | SCENE= }} | {{STRUCTURE_3esk| PDB=3esk | SCENE= }} | ||
===Structure of HOP TPR2A domain in complex with the non-cognate Hsc70 peptide ligand=== | ===Structure of HOP TPR2A domain in complex with the non-cognate Hsc70 peptide ligand=== | ||
{{ABSTRACT_PUBMED_19586912}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/STIP1_HUMAN STIP1_HUMAN]] Mediates the association of the molecular chaperones HSC70 and HSP90 (HSPCA and HSPCB). [[http://www.uniprot.org/uniprot/HSP7C_HUMAN HSP7C_HUMAN]] Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex.<ref>PMID:10722728</ref> | |||
==About this Structure== | ==About this Structure== | ||
[[3esk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ | [[3esk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ESK OCA]. | ||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID:019586912</ref><references group="xtra"/> | <ref group="xtra">PMID:019586912</ref><references group="xtra"/><references/> | ||
[[Category: | [[Category: Human]] | ||
[[Category: Kajander, T.]] | [[Category: Kajander, T.]] | ||
[[Category: Regan, L.]] | [[Category: Regan, L.]] | ||
Revision as of 07:04, 2 April 2014
Structure of HOP TPR2A domain in complex with the non-cognate Hsc70 peptide ligand
Template:ABSTRACT PUBMED 19586912
Function
[STIP1_HUMAN] Mediates the association of the molecular chaperones HSC70 and HSP90 (HSPCA and HSPCB). [HSP7C_HUMAN] Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex.[1]
About this Structure
3esk is a 2 chain structure with sequence from Human. Full crystallographic information is available from OCA.
Reference
- Kajander T, Sachs JN, Goldman A, Regan L. Electrostatic interactions of Hsp-organizing protein tetratricopeptide domains with Hsp70 and Hsp90: computational analysis and protein engineering. J Biol Chem. 2009 Sep 11;284(37):25364-74. Epub 2009 Jul 7. PMID:19586912 doi:10.1074/jbc.M109.033894
