3ao2: Difference between revisions

Line 1:

~~[[Image:3ao2.png|left|200px]]~~

==Fragment-based approach to the design of ligands targeting a novel site on HIV-1 integrase==

~~{{STRUCTURE_3ao2| PDB=3ao2 | SCENE= }}~~

== Structural highlights ==

<table><tr><td colspan='2'>[[3ao2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AO2 OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3AO2 FirstGlance].

===Fragment-based approach to the design of ligands targeting a novel site on HIV-1 integrase===

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=AVX:3-(7-BROMO-1,3-BENZODIOXOL-5-YL)-1-METHYL-1H-PYRAZOL-5-AMINE'>AVX</scene>, <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DTT:2,3-DIHYDROXY-1,4-DITHIOBUTANE'>DTT</scene>, <scene name='pdbligand=DTV:(2S,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL'>DTV</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>

<tr id='gene'><td class="sblockLbl">[[Gene|Gene:]]</td><td class="sblockDat">pol ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 Human immunodeficiency virus 1])</td></tr>

==~~About this Structure~~==

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ao2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ao2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ao2 RCSB], [http://www.ebi.ac.uk/pdbsum/3ao2 PDBsum]</td></tr>

[[3ao2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AO2 OCA].

</table>

__TOC__

==~~Reference~~==

</StructureSection>

<~~ref group~~="~~xtra~~">~~PMID~~:~~021275048~~</~~ref~~><~~references group~~="~~xtra~~"/>

[[Category: Human immunodeficiency virus 1]]

[[Category: Chalmers, D K.]]

[[Category: Chalmers, D K]]

[[Category: Headey, S J.]]

[[Category: Headey, S J]]

[[Category: Parker, M W.]]

[[Category: Parker, M W]]

[[Category: Scanlon, M J.]]

[[Category: Scanlon, M J]]

[[Category: Wielens, J.]]

[[Category: Wielens, J]]

[[Category: Aid]]

[[Category: Dna binding]]

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-[[Image:3ao2.png|left|200px]]
+==Fragment-based approach to the design of ligands targeting a novel site on HIV-1 integrase==
+<StructureSection load='3ao2' size='340' side='right' caption='[[3ao2]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
-{{STRUCTURE_3ao2|  PDB=3ao2  |  SCENE=  }}
+== Structural highlights ==
+<table><tr><td colspan='2'>[[3ao2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AO2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3AO2 FirstGlance]. <br>
-===Fragment-based approach to the design of ligands targeting a novel site on HIV-1 integrase===
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AVX:3-(7-BROMO-1,3-BENZODIOXOL-5-YL)-1-METHYL-1H-PYRAZOL-5-AMINE'>AVX</scene>, <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DTT:2,3-DIHYDROXY-1,4-DITHIOBUTANE'>DTT</scene>, <scene name='pdbligand=DTV:(2S,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL'>DTV</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1bl3|1bl3]], [[3l3u|3l3u]], [[3ovn|3ovn]], [[3ao1|3ao1]], [[3ao3|3ao3]], [[3ao4|3ao4]], [[3ao5|3ao5]]</td></tr>
+<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">pol ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 Human immunodeficiency virus 1])</td></tr>
-==About this Structure==
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ao2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ao2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ao2 RCSB], [http://www.ebi.ac.uk/pdbsum/3ao2 PDBsum]</span></td></tr>
-[[3ao2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AO2 OCA].
+</table>
+__TOC__
-==Reference==
+</StructureSection>
-<ref group="xtra">PMID:021275048</ref><references group="xtra"/>
 [[Category: Human immunodeficiency virus 1]]
-[[Category: Chalmers, D K.]]
+[[Category: Chalmers, D K]]
-[[Category: Headey, S J.]]
+[[Category: Headey, S J]]
-[[Category: Parker, M W.]]
+[[Category: Parker, M W]]
-[[Category: Scanlon, M J.]]
+[[Category: Scanlon, M J]]
-[[Category: Wielens, J.]]
+[[Category: Wielens, J]]
 [[Category: Aid]]
 [[Category: Dna binding]]