2kxs: Difference between revisions

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[[Image:2kxs.png|left|200px]]
==ZO1 ZU5 domain in complex with GRINL1A peptide==
<StructureSection load='2kxs' size='340' side='right' caption='[[2kxs]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2kxs]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KXS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KXS FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2kxr|2kxr]]</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TJP1, ZO1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kxs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kxs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2kxs RCSB], [http://www.ebi.ac.uk/pdbsum/2kxs PDBsum]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Zonula occludens (ZO)-1 is a multi-domain scaffold protein known to have critical roles in the establishment of cell-cell adhesions and the maintenance of stable tissue structures through the targeting, anchoring, and clustering of transmembrane adhesion molecules and cytoskeletal proteins. Here, we report that ZO-1 directly binds to MRCKbeta, a Cdc42 effector kinase that modulates cell protrusion and migration, at the leading edge of migrating cells. Structural studies reveal that the binding of a beta hairpin from GRINL1A converts ZO-1 ZU5 into a complete ZU5-fold. A similar interaction mode is likely to occur between ZO-1 ZU5 and MRCKbeta. The interaction between ZO-1 and MRCKbeta requires the kinase to be primed by Cdc42 due to the closed conformation of the kinase. Formation of the ZO-1/MRCKbeta complex enriches the kinase at the lamellae of migrating cells. Disruption of the ZO-1/MRCKbeta complex inhibits MRCKbeta-mediated cell migration. These results demonstrate that ZO-1, a classical scaffold protein with accepted roles in maintaining cell-cell adhesions in stable tissues, also has an active role in cell migration during processes such as tissue development and remodelling.


{{STRUCTURE_2kxs|  PDB=2kxs  |  SCENE=  }}
Cdc42-dependent formation of the ZO-1/MRCKbeta complex at the leading edge controls cell migration.,Huo L, Wen W, Wang R, Kam C, Xia J, Feng W, Zhang M EMBO J. 2011 Feb 16;30(4):665-78. Epub 2011 Jan 14. PMID:21240187<ref>PMID:21240187</ref>


===ZO1 ZU5 domain in complex with GRINL1A peptide===
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 
</div>
{{ABSTRACT_PUBMED_21240187}}
== References ==
 
<references/>
==About this Structure==
__TOC__
[[2kxs]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KXS OCA].
</StructureSection>
 
==Reference==
<ref group="xtra">PMID:021240187</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Wen, W.]]
[[Category: Wen, W]]
[[Category: Zhang, M.]]
[[Category: Zhang, M]]
[[Category: Beta-barrel]]
[[Category: Beta-barrel]]
[[Category: Protein binding]]
[[Category: Protein binding]]
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