3zm6: Difference between revisions

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'''Unreleased structure'''
{{STRUCTURE_3zm6|  PDB=3zm6  |  SCENE=  }}
===CRYSTAL STRUCTURE OF MURF LIGASE IN COMPLEX WITH CYANOTHIOPHENE INHIBITOR===
{{ABSTRACT_PUBMED_23786712}}


The entry 3zm6 is ON HOLD  until Paper Publication
==Function==
[[http://www.uniprot.org/uniprot/Q8DNV6_STRR6 Q8DNV6_STRR6]] Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity).[RuleBase:RU004136]


Authors: Hrast, M., Turk, S., Sosic, I., Knez, D., Randall, C.P., Barreteau, H., Contreras-Martel, C., Dessen, A., ONeill, A.J., Mengin-Lecreulx, D., Blanot, D., Gobec, S.
==About this Structure==
[[3zm6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_pneumoniae_r6 Streptococcus pneumoniae r6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZM6 OCA].  


Description: CRYSTAL STRUCTURE OF MURF LIGASE IN COMPLEX WITH CYANOTHIOPHENE INHIBITOR
==Reference==
<ref group="xtra">PMID:023786712</ref><references group="xtra"/><references/>
[[Category: Streptococcus pneumoniae r6]]
[[Category: UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase]]
[[Category: Barreteau, H.]]
[[Category: Blanot, D.]]
[[Category: Contreras-Martel, C.]]
[[Category: Dessen, A.]]
[[Category: Gobec, S.]]
[[Category: Hrast, M.]]
[[Category: Knez, D.]]
[[Category: Mengin-Lecreulx, D.]]
[[Category: ONeill, A J.]]
[[Category: Randall, C P.]]
[[Category: Sosic, I.]]
[[Category: Turk, S.]]
[[Category: Adp-forming enzyme]]
[[Category: Atp-binding]]
[[Category: Cell cycle]]
[[Category: Cell divison]]
[[Category: Cell shape]]
[[Category: Cell wall]]
[[Category: Ligase]]
[[Category: Nucleotide-binding]]
[[Category: Peptidoglycan synthesis]]

Revision as of 14:06, 3 July 2013

Template:STRUCTURE 3zm6

CRYSTAL STRUCTURE OF MURF LIGASE IN COMPLEX WITH CYANOTHIOPHENE INHIBITOR

Template:ABSTRACT PUBMED 23786712

Function

[Q8DNV6_STRR6] Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity).[RuleBase:RU004136]

About this Structure

3zm6 is a 1 chain structure with sequence from Streptococcus pneumoniae r6. Full crystallographic information is available from OCA.

Reference

  1. Hrast M, Turk S, Sosic I, Knez D, Randall CP, Barreteau H, Contreras-Martel C, Dessen A, O'Neill AJ, Mengin-Lecreulx D, Blanot D, Gobec S. Structure-activity relationships of new cyanothiophene inhibitors of the essential peptidoglycan biosynthesis enzyme MurF. Eur J Med Chem. 2013 May 21;66C:32-45. doi: 10.1016/j.ejmech.2013.05.013. PMID:23786712 doi:10.1016/j.ejmech.2013.05.013

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