4ilw: Difference between revisions

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'''Unreleased structure'''
{{STRUCTURE_4ilw|  PDB=4ilw  |  SCENE=  }}
===Complex of matrix metalloproteinase-10 catalytic domain (MMP-10cd) with tissue inhibitor of metalloproteinases-2 (TIMP-2)===
{{ABSTRACT_PUBMED_24073280}}


The entry 4ilw is ON HOLD until Paper Publication
==Function==
[[http://www.uniprot.org/uniprot/TIMP2_HUMAN TIMP2_HUMAN]] Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16 and MMP-19.<ref>PMID:2793861</ref> <ref>PMID:2554304</ref> <ref>PMID:11710594</ref> [[http://www.uniprot.org/uniprot/MMP10_HUMAN MMP10_HUMAN]] Can degrade fibronectin, gelatins of type I, III, IV, and V; weakly collagens III, IV, and V. Activates procollagenase.


Authors: Batra, J., Soares, A.S., Radisky, E.S.
==About this Structure==
[[4ilw]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ILW OCA].  


Description: Complex of matrix metalloproteinase-10 catalytic domain (MMP-10cd) with tissue inhibitor of metalloproteinases-2 (TIMP-2)
==Reference==
<ref group="xtra">PMID:024073280</ref><references group="xtra"/><references/>
[[Category: Stromelysin 2]]
[[Category: Batra, J.]]
[[Category: Radisky, E S.]]
[[Category: Soares, A S.]]
[[Category: Hydrolase-hydrolase inhibitor complex]]
[[Category: Metalloproteinase]]
[[Category: Metzincin]]
[[Category: Ob-fold]]
[[Category: Protease inhibitor]]
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