4is8: Difference between revisions

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-'''Unreleased structure'''
+{{STRUCTURE_4is8|  PDB=4is8  |  SCENE=  }}
+===Divergent sequence tunes ligand sensitivity in phospholipid-regulated hormone receptors===
-The entry 4is8 is ON HOLD
+==Function==
+[[http://www.uniprot.org/uniprot/NR5A2_HUMAN NR5A2_HUMAN]] Binds to the sequence element 5'-AACGACCGACCTTGAG-3' of the enhancer II of hepatitis B virus genes, a critical cis-element of their expression and regulation. May be responsible for the liver-specific activity of enhancer II, probably in combination with other hepatocyte transcription factors. Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver. May also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development.
-Authors: Musille, P.M., Pathak, M.C., Ortlund, E.A.
+==About this Structure==
+[[4is8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IS8 OCA].
-Description: A six-residue insertion in the human lrh-1 is sufficient to induce the active conformation in the absence of ligand
+[[Category: Homo sapiens]]
+[[Category: Musille, P M.]]
+[[Category: Ortlund, E A.]]
+[[Category: Pathak, M C.]]
+[[Category: Ligand binding domain]]
+[[Category: Transcription]]

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