3val: Difference between revisions
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{{STRUCTURE_3val| PDB=3val | SCENE= }} | {{STRUCTURE_3val| PDB=3val | SCENE= }} | ||
===Structure of U2AF65 variant with BrU5C1 DNA=== | ===Structure of U2AF65 variant with BrU5C1 DNA=== | ||
{{ABSTRACT_PUBMED_23376934}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/U2AF2_HUMAN U2AF2_HUMAN]] Necessary for the splicing of pre-mRNA. Induces cardiac troponin-T (TNNT2) pre-mRNA exon inclusion in muscle. Regulates the TNNT2 exon 5 inclusion through competition with MBNL1. Binds preferentially to a single-stranded structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Required for the export of mRNA out of the nucleus, even if the mRNA is encoded by an intron-less gene. Represses the splicing of MAPT/Tau exon 10.<ref>PMID:15009664</ref> <ref>PMID:19470458</ref> <ref>PMID:19574390</ref> | |||
==About this Structure== | ==About this Structure== | ||
[[3val]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VAL OCA]. | [[3val]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VAL OCA]. | ||
==Reference== | |||
<ref group="xtra">PMID:023376934</ref><references group="xtra"/><references/> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Frato, K H.]] | [[Category: Frato, K H.]] | ||
