1zzl: Difference between revisions

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[[Image:1zzl.gif|left|200px]]<br /><applet load="1zzl" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1zzl.gif|left|200px]]
caption="1zzl, resolution 2.000&Aring;" />
 
'''Crystal structure of P38 with triazolopyridine'''<br />
{{Structure
|PDB= 1zzl |SIZE=350|CAPTION= <scene name='initialview01'>1zzl</scene>, resolution 2.000&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=TZY:6-[4-(4-FLUOROPHENYL)-1,3-OXAZOL-5-YL]-3-ISOPROPYL[1,2,4]TRIAZOLO[4,3-A]PYRIDINE'>TZY</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1]
|GENE= MAPK14, CSBP, CSBP1, CSBP2, MXI2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
}}
 
'''Crystal structure of P38 with triazolopyridine'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1ZZL is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=TZY:'>TZY</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZZL OCA].  
1ZZL is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZZL OCA].  


==Reference==
==Reference==
Theoretical and experimental design of atypical kinase inhibitors: application to p38 MAP kinase., McClure KF, Abramov YA, Laird ER, Barberia JT, Cai W, Carty TJ, Cortina SR, Danley DE, Dipesa AJ, Donahue KM, Dombroski MA, Elliott NC, Gabel CA, Han S, Hynes TR, Lemotte PK, Mansour MN, Marr ES, Letavic MA, Pandit J, Ripin DB, Sweeney FJ, Tan D, Tao Y, J Med Chem. 2005 Sep 8;48(18):5728-37. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16134941 16134941]
Theoretical and experimental design of atypical kinase inhibitors: application to p38 MAP kinase., McClure KF, Abramov YA, Laird ER, Barberia JT, Cai W, Carty TJ, Cortina SR, Danley DE, Dipesa AJ, Donahue KM, Dombroski MA, Elliott NC, Gabel CA, Han S, Hynes TR, Lemotte PK, Mansour MN, Marr ES, Letavic MA, Pandit J, Ripin DB, Sweeney FJ, Tan D, Tao Y, J Med Chem. 2005 Sep 8;48(18):5728-37. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16134941 16134941]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Non-specific serine/threonine protein kinase]]
[[Category: Non-specific serine/threonine protein kinase]]
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[[Category: transferase]]
[[Category: transferase]]


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