3f5c: Difference between revisions

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[[~~Image~~:3f5c.~~png|left|200px~~]]

==Structure of Dax-1:LRH-1 complex==

== Structural highlights ==

<table><tr><td colspan='2'>[[3f5c]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F5C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3F5C FirstGlance]. <br>

</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Nr5a2, Lrh1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]), Nr0b1, Ahch, Dax1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3f5c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f5c OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3f5c RCSB], [http://www.ebi.ac.uk/pdbsum/3f5c PDBsum]</span></td></tr>

</table>

== Publication Abstract from PubMed ==

The Dax-1 protein is an enigmatic nuclear receptor that lacks an expected DNA binding domain, yet functions as a potent corepressor of nuclear receptors. Here we report the structure of Dax-1 bound to one of its targets, liver receptor homolog 1 (LRH-1). Unexpectedly, Dax-1 binds to LRH-1 using a new module, a repressor helix built from a family conserved sequence motif, PCFXXLP. Mutations in this repressor helix that are linked with human endocrine disorders dissociate the complex and attenuate Dax-1 function. The structure of the Dax-1:LRH-1 complex provides the molecular mechanism for the function of Dax-1 as a potent transcriptional repressor.

~~{{STRUCTURE_3f5c| PDB=3f5c | SCENE= }}~~

The structure of corepressor Dax-1 bound to its target nuclear receptor LRH-1.,Sablin EP, Woods A, Krylova IN, Hwang P, Ingraham HA, Fletterick RJ Proc Natl Acad Sci U S A. 2008 Nov 25;105(47):18390-5. Epub 2008 Nov 17. PMID:19015525<ref>PMID:19015525</ref>

~~===Structure~~ of ~~Dax-1:LRH-1 complex===~~

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>

</div>

~~{{ABSTRACT_PUBMED_19015525}}~~

== References ==

==~~About this Structure~~==

__TOC__

~~[[3f5c]] is a 3 chain structure with sequence from [http:~~//~~en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F5C OCA].~~

</StructureSection>

[[Category: Mus musculus]]

[[Category: Fletterick, R J.]]

[[Category: Fletterick, R J]]

[[Category: Sablin, E P.]]

[[Category: Sablin, E P]]

[[Category: Dna-binding]]

[[Category: Lipid-binding]]

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-[[Image:3f5c.png|left|200px]]
+==Structure of Dax-1:LRH-1 complex==
+<StructureSection load='3f5c' size='340' side='right' caption='[[3f5c]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[3f5c]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F5C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3F5C FirstGlance]. <br>
+</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Nr5a2, Lrh1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]), Nr0b1, Ahch, Dax1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3f5c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f5c OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3f5c RCSB], [http://www.ebi.ac.uk/pdbsum/3f5c PDBsum]</span></td></tr>
+</table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+The Dax-1 protein is an enigmatic nuclear receptor that lacks an expected DNA binding domain, yet functions as a potent corepressor of nuclear receptors. Here we report the structure of Dax-1 bound to one of its targets, liver receptor homolog 1 (LRH-1). Unexpectedly, Dax-1 binds to LRH-1 using a new module, a repressor helix built from a family conserved sequence motif, PCFXXLP. Mutations in this repressor helix that are linked with human endocrine disorders dissociate the complex and attenuate Dax-1 function. The structure of the Dax-1:LRH-1 complex provides the molecular mechanism for the function of Dax-1 as a potent transcriptional repressor.
-{{STRUCTURE_3f5c|  PDB=3f5c  |  SCENE=  }}
+The structure of corepressor Dax-1 bound to its target nuclear receptor LRH-1.,Sablin EP, Woods A, Krylova IN, Hwang P, Ingraham HA, Fletterick RJ Proc Natl Acad Sci U S A. 2008 Nov 25;105(47):18390-5. Epub 2008 Nov 17. PMID:19015525<ref>PMID:19015525</ref>
-===Structure of Dax-1:LRH-1 complex===
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
-{{ABSTRACT_PUBMED_19015525}}
+== References ==
+<references/>
-==About this Structure==
+__TOC__
-[[3f5c]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F5C OCA].
+</StructureSection>
 [[Category: Mus musculus]]
-[[Category: Fletterick, R J.]]
+[[Category: Fletterick, R J]]
-[[Category: Sablin, E P.]]
+[[Category: Sablin, E P]]
 [[Category: Dna-binding]]
 [[Category: Lipid-binding]]