2lru: Difference between revisions
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{{STRUCTURE_2lru| PDB=2lru | SCENE= }} | {{STRUCTURE_2lru| PDB=2lru | SCENE= }} | ||
===Solution Structure of the WNK1 Autoinhibitory Domain=== | ===Solution Structure of the WNK1 Autoinhibitory Domain=== | ||
{{ABSTRACT_PUBMED_23376100}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/WNK1_RAT WNK1_RAT]] Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SCNN1A, SCNN1B, SCNN1D and SGK1. Controls sodium and chloride ion transport by inhibiting the activity of WNK4, by either phosphorylating the kinase or via an interaction between WNK4 and the autoinhibitory domain of WNK1. WNK4 regulates the activity of the thiazide-sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation. WNK1 may also play a role in actin cytoskeletal reorganization. Phosphorylates NEDD4L.<ref>PMID:17975670</ref> <ref>PMID:20525693</ref> | |||
==About this Structure== | ==About this Structure== | ||
[[2lru]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LRU OCA]. | [[2lru]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LRU OCA]. | ||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Non-specific serine/threonine protein kinase]] | [[Category: Non-specific serine/threonine protein kinase]] | ||
[[Category: Rattus norvegicus]] | [[Category: Rattus norvegicus]] | ||
