4idl: Difference between revisions

Line 1:

[[~~Image~~:4idl.~~png|left|200px~~]]

==Low melting temperature Anti-Cholera Toxin Llama VHH domain==

== Structural highlights ==

<table><tr><td colspan='2'>[[4idl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lama_glama Lama glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IDL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IDL FirstGlance]. <br>

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4idl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4idl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4idl RCSB], [http://www.ebi.ac.uk/pdbsum/4idl PDBsum]</span></td></tr>

</table>

== Publication Abstract from PubMed ==

Variable heavy domains derived from the heavy-chain-only antibodies found in camelids (V(H)H domains) are known for their thermal stability. Here, the structure of A9, an anti-cholera toxin V(H)H domain (K(d) = 77 +/- 5 nM) that has an unusually low melting temperature of 319.9 +/- 1.6 K, is reported. The CDR3 residues of A9 form a beta-hairpin that is directed away from the former V(H)-V(L) interfacial surface, exposing hydrophobic residues to the solvent. A DALI structural similarity search showed that this CDR3 conformation is uncommon.

~~{{STRUCTURE_4idl| PDB=4idl | SCENE= }}~~

Structure of a low-melting-temperature anti-cholera toxin: llama V(H)H domain.,Legler PM, Zabetakis D, Anderson GP, Lam A, Hol WG, Goldman ER Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Feb 1;69(Pt 2):90-3. doi: , 10.1107/S1744309112050750. Epub 2013 Jan 26. PMID:23385744<ref>PMID:23385744</ref>

~~===Low melting temperature Anti-Cholera Toxin Llama VHH domain===~~

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>

</div>

~~{{ABSTRACT_PUBMED_23385744}}~~

==See Also==

*[[Monoclonal Antibody|Monoclonal Antibody]]

==~~About this Structure~~==

== References ==

[[~~4idl~~]] ~~is a 1 chain structure with sequence from [http:~~//~~en.wikipedia.org/wiki/Lama_glama Lama glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IDL OCA].~~

__TOC__

</StructureSection>

[[Category: Lama glama]]

[[Category: Hol, W G.J.]]

[[Category: Hol, W G.J]]

[[Category: Lam, A.]]

[[Category: Lam, A]]

[[Category: Legler, P M.]]

[[Category: Legler, P M]]

[[Category: Antibody]]

[[Category: Cholera toxin]]

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@@ Line 1: / Line 1: @@
-[[Image:4idl.png|left|200px]]
+==Low melting temperature Anti-Cholera Toxin Llama VHH domain==
+<StructureSection load='4idl' size='340' side='right' caption='[[4idl]], [[Resolution|resolution]] 2.09&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4idl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lama_glama Lama glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IDL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IDL FirstGlance]. <br>
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4idl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4idl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4idl RCSB], [http://www.ebi.ac.uk/pdbsum/4idl PDBsum]</span></td></tr>
+</table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Variable heavy domains derived from the heavy-chain-only antibodies found in camelids (V(H)H domains) are known for their thermal stability. Here, the structure of A9, an anti-cholera toxin V(H)H domain (K(d) = 77 +/- 5 nM) that has an unusually low melting temperature of 319.9 +/- 1.6 K, is reported. The CDR3 residues of A9 form a beta-hairpin that is directed away from the former V(H)-V(L) interfacial surface, exposing hydrophobic residues to the solvent. A DALI structural similarity search showed that this CDR3 conformation is uncommon.
-{{STRUCTURE_4idl|  PDB=4idl  |  SCENE=  }}
+Structure of a low-melting-temperature anti-cholera toxin: llama V(H)H domain.,Legler PM, Zabetakis D, Anderson GP, Lam A, Hol WG, Goldman ER Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Feb 1;69(Pt 2):90-3. doi: , 10.1107/S1744309112050750. Epub 2013 Jan 26. PMID:23385744<ref>PMID:23385744</ref>
-===Low melting temperature Anti-Cholera Toxin Llama VHH domain===
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
-{{ABSTRACT_PUBMED_23385744}}
+==See Also==
+*[[Monoclonal Antibody|Monoclonal Antibody]]
-==About this Structure==
+== References ==
-[[4idl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lama_glama Lama glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IDL OCA].
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Lama glama]]
-[[Category: Hol, W G.J.]]
+[[Category: Hol, W G.J]]
-[[Category: Lam, A.]]
+[[Category: Lam, A]]
-[[Category: Legler, P M.]]
+[[Category: Legler, P M]]
 [[Category: Antibody]]
 [[Category: Cholera toxin]]