2a2k: Difference between revisions

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[[Image:2a2k.gif|left|200px]]<br /><applet load="2a2k" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2a2k.gif|left|200px]]
caption="2a2k, resolution 1.52&Aring;" />
 
'''Crystal Structure of an active site mutant, C473S, of Cdc25B Phosphatase Catalytic Domain'''<br />
{{Structure
|PDB= 2a2k |SIZE=350|CAPTION= <scene name='initialview01'>2a2k</scene>, resolution 1.52&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene> and <scene name='pdbligand=SO4:SULFATE ION'>SO4</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48]
|GENE= CDC25B, CDC25HU2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
}}
 
'''Crystal Structure of an active site mutant, C473S, of Cdc25B Phosphatase Catalytic Domain'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2A2K is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=CL:'>CL</scene> and <scene name='pdbligand=SO4:'>SO4</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A2K OCA].  
2A2K is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A2K OCA].  


==Reference==
==Reference==
Experimental validation of the docking orientation of Cdc25 with its Cdk2-CycA protein substrate., Sohn J, Parks JM, Buhrman G, Brown P, Kristjansdottir K, Safi A, Edelsbrunner H, Yang W, Rudolph J, Biochemistry. 2005 Dec 20;44(50):16563-73. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16342947 16342947]
Experimental validation of the docking orientation of Cdc25 with its Cdk2-CycA protein substrate., Sohn J, Parks JM, Buhrman G, Brown P, Kristjansdottir K, Safi A, Edelsbrunner H, Yang W, Rudolph J, Biochemistry. 2005 Dec 20;44(50):16563-73. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16342947 16342947]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Protein-tyrosine-phosphatase]]
[[Category: Protein-tyrosine-phosphatase]]
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[[Category: substrate trapping]]
[[Category: substrate trapping]]


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