2m4h: Difference between revisions

Line 1:

~~'''Unreleased~~ structure~~'''~~

===Solution structure of the Core Domain (10-76) of the Feline Calicivirus VPg protein===

~~The entry 2m4h~~ is ~~ON HOLD~~

==Function==

[[http://www.uniprot.org/uniprot/POLG_FCVF9 POLG_FCVF9]] NTPase presumably plays a role in replication. Despite having similarities with helicases, does not seem to display any helicase activity (By similarity). Viral genome-linked protein is covalently linked to the 5'-end of the positive-strand, negative-strand genomic RNAs and subgenomic RNA. Acts as a genome-linked replication primer. May recruit ribosome to viral RNA thereby promoting viral proteins translation (By similarity). Protease-polymerase p76 processes the polyprotein: Pro-Pol is first released by autocleavage, then all other proteins are cleaved. Cleaves host translation initiation factor eIF4G1 and eIF4G2 thereby inducing a shutdown of host protein synthesis. This shutdown may not prevent viral mRNA from being translated since viral Vpg replaces the cap. May cleave host polyadenylate-binding protein thereby inhibiting cellular translation. It is also a RNA-directed RNA polymerase which replicates genomic and antigenomic viral RNA by recognizing specific signals. Transcribes also a subgenomic mRNA by initiating RNA synthesis internally on antigenomic RNA. This sgRNA encodes for structural proteins. Catalyzes the covalent attachment VPg with viral RNAs (By similarity).

~~Authors~~: ~~Kwok, R~~.N.~~, Leen, E~~.N., Birtley, J.R.~~, Prater~~, S.N., ~~Simpson~~, P.J.~~, Curry~~, S.~~, Matthews~~, S., ~~Marchant,~~ J.

==About this Structure==

[[2m4h]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Feline_calicivirus_(strain_f9) Feline calicivirus (strain f9)]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M4H OCA].

~~Description~~: ~~Solution structure of the Core Domain (10-76) of the Feline Calicivirus VPg~~ protein

[[Category: Birtley, J R.]]

[[Category: Curry, S.]]

[[Category: Kwok, R N.]]

[[Category: Leen, E N.]]

[[Category: Marchant, J.]]

[[Category: Matthews, S.]]

[[Category: Prater, S N.]]

[[Category: Simpson, P J.]]

[[Category: Ns5]]

[[Category: Viral protein]]

[[Category: Vpg]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_2m4h|  PDB=2m4h  |  SCENE=  }}
+===Solution structure of the Core Domain (10-76) of the Feline Calicivirus VPg protein===
+{{ABSTRACT_PUBMED_23487472}}
-The entry 2m4h is ON HOLD
+==Function==
+[[http://www.uniprot.org/uniprot/POLG_FCVF9 POLG_FCVF9]] NTPase presumably plays a role in replication. Despite having similarities with helicases, does not seem to display any helicase activity (By similarity).  Viral genome-linked protein is covalently linked to the 5'-end of the positive-strand, negative-strand genomic RNAs and subgenomic RNA. Acts as a genome-linked replication primer. May recruit ribosome to viral RNA thereby promoting viral proteins translation (By similarity).  Protease-polymerase p76 processes the polyprotein: Pro-Pol is first released by autocleavage, then all other proteins are cleaved. Cleaves host translation initiation factor eIF4G1 and eIF4G2 thereby inducing a shutdown of host protein synthesis. This shutdown may not prevent viral mRNA from being translated since viral Vpg replaces the cap. May cleave host polyadenylate-binding protein thereby inhibiting cellular translation. It is also a RNA-directed RNA polymerase which replicates genomic and antigenomic viral RNA by recognizing specific signals. Transcribes also a subgenomic mRNA by initiating RNA synthesis internally on antigenomic RNA. This sgRNA encodes for structural proteins. Catalyzes the covalent attachment VPg with viral RNAs (By similarity).
-Authors: Kwok, R.N., Leen, E.N., Birtley, J.R., Prater, S.N., Simpson, P.J., Curry, S., Matthews, S., Marchant, J.
+==About this Structure==
+[[2m4h]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Feline_calicivirus_(strain_f9) Feline calicivirus (strain f9)]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M4H OCA].
-Description: Solution structure of the Core Domain (10-76) of the Feline Calicivirus VPg protein
+[[Category: Birtley, J R.]]
+[[Category: Curry, S.]]
+[[Category: Kwok, R N.]]
+[[Category: Leen, E N.]]
+[[Category: Marchant, J.]]
+[[Category: Matthews, S.]]
+[[Category: Prater, S N.]]
+[[Category: Simpson, P J.]]
+[[Category: Ns5]]
+[[Category: Viral protein]]
+[[Category: Vpg]]