4j0p: Difference between revisions

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'''Unreleased structure'''
{{STRUCTURE_4j0p|  PDB=4j0p  |  SCENE=  }}
===CRYSTAL STRUCTURE OF BACE-1 IN COMPLEX WITH 5-Cyano-pyridine-2-carboxylic acid [3-((S)-2-amino-4-methyl-5,6-dihydro-4H-[1,3]oxazin-4-yl)-4-fluoro-phenyl]-amide===
{{ABSTRACT_PUBMED_23590342}}


The entry 4j0p is ON HOLD until Paper Publication
==Function==
[[http://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>  


Authors: Kuglstatter, A., Stihle, M.
==About this Structure==
[[4j0p]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J0P OCA].  


Description: CRYSTAL STRUCTURE OF BACE-1 IN COMPLEX WITH 5-Cyano-pyridine-2-carboxylic acid [3-((S)-2-amino-4-methyl-5,6-dihydro-4H-[1,3]oxazin-4-yl)-4-fluoro-phenyl]-amide
==Reference==
<ref group="xtra">PMID:023590342</ref><references group="xtra"/><references/>
[[Category: Memapsin 2]]
[[Category: Kuglstatter, A.]]
[[Category: Stihle, M.]]
[[Category: Hydrolase-hydrolase inhibitor complex]]
[[Category: Protease inhibitor]]
Retrieved from "https://proteopedia.org/4j0p"