2a49: Difference between revisions

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[[Image:2a49.gif|left|200px]]<br /><applet load="2a49" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2a49.gif|left|200px]]
caption="2a49, resolution 1.43&Aring;" />
 
'''Crystal structure of clavulanic acid bound to E166A variant of SHV-1 beta-lactamase'''<br />
{{Structure
|PDB= 2a49 |SIZE=350|CAPTION= <scene name='initialview01'>2a49</scene>, resolution 1.43&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=TEM:N-(2-HYDROXY-4-OXO-BUTYL)-N-(3-OXO-TRANSPROPENYL)AMINE'>TEM</scene>, <scene name='pdbligand=MA4:CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE'>MA4</scene> and <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID'>EPE</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6]
|GENE= bla, shv1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=573 Klebsiella pneumoniae])
}}
 
'''Crystal structure of clavulanic acid bound to E166A variant of SHV-1 beta-lactamase'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2A49 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Klebsiella_pneumoniae Klebsiella pneumoniae] with <scene name='pdbligand=TEM:'>TEM</scene>, <scene name='pdbligand=MA4:'>MA4</scene> and <scene name='pdbligand=EPE:'>EPE</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A49 OCA].  
2A49 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Klebsiella_pneumoniae Klebsiella pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A49 OCA].  


==Reference==
==Reference==
High resolution crystal structures of the trans-enamine intermediates formed by sulbactam and clavulanic acid and E166A SHV-1 {beta}-lactamase., Padayatti PS, Helfand MS, Totir MA, Carey MP, Carey PR, Bonomo RA, van den Akker F, J Biol Chem. 2005 Oct 14;280(41):34900-7. Epub 2005 Jul 29. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16055923 16055923]
High resolution crystal structures of the trans-enamine intermediates formed by sulbactam and clavulanic acid and E166A SHV-1 {beta}-lactamase., Padayatti PS, Helfand MS, Totir MA, Carey MP, Carey PR, Bonomo RA, van den Akker F, J Biol Chem. 2005 Oct 14;280(41):34900-7. Epub 2005 Jul 29. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16055923 16055923]
[[Category: Beta-lactamase]]
[[Category: Beta-lactamase]]
[[Category: Klebsiella pneumoniae]]
[[Category: Klebsiella pneumoniae]]
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[[Category: penicillinase]]
[[Category: penicillinase]]


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