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[[Image:4j40.jpg|left|200px]]
==Crystal structure of the dual-domain GGDEF-EAL module of FimX from Pseudomonas aeruginosa==
<StructureSection load='4j40' size='340' side='right' caption='[[4j40]], [[Resolution|resolution]] 2.99&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4j40]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_pao1 Pseudomonas aeruginosa pao1]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3hvb 3hvb]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J40 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4J40 FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3hv8|3hv8]], [[3hv9|3hv9]], [[3hva|3hva]]</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">fimX, PA4959 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=208964 Pseudomonas aeruginosa PAO1])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cyclic-guanylate-specific_phosphodiesterase Cyclic-guanylate-specific phosphodiesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.52 3.1.4.52] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4j40 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j40 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4j40 RCSB], [http://www.ebi.ac.uk/pdbsum/4j40 PDBsum]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Bacterial pathogenesis involves social behavior including biofilm formation and swarming, processes that are regulated by the bacterially unique second messenger cyclic di-GMP (c-di-GMP). Diguanylate cyclases containing GGDEF and phosphodiesterases containing EAL domains have been identified as the enzymes controlling cellular c-di-GMP levels, yet less is known regarding signal transmission and the targets of c-di-GMP. FimX, a protein from Pseudomonas aeruginosa that governs twitching motility, belongs to a large subfamily containing both GGDEF and EAL domains. Biochemical and structural analyses reveals its function as a high-affinity receptor for c-di-GMP. A model for full-length FimX was generated combining solution scattering data and crystal structures of the degenerate GGDEF and EAL domains. Although FimX forms a dimer in solution via the N-terminal domains, a crystallographic EAL domain dimer suggests modes for the regulation of FimX by c-di-GMP binding. The results provide the structural basis for c-di-GMP sensing via degenerate phosphodiesterases.


{{STRUCTURE_4j40|  PDB=4j40  |  SCENE=  }}
Structural analysis of the GGDEF-EAL domain-containing c-di-GMP receptor FimX.,Navarro MV, De N, Bae N, Wang Q, Sondermann H Structure. 2009 Aug 12;17(8):1104-16. PMID:19679088<ref>PMID:19679088</ref>


===Crystal structure of the dual-domain GGDEF-EAL module of FimX from Pseudomonas aeruginosa===
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 
</div>
{{ABSTRACT_PUBMED_19679088}}
== References ==
 
<references/>
==About this Structure==
__TOC__
[[4j40]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_pao1 Pseudomonas aeruginosa pao1]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3hvb 3hvb]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J40 OCA].
</StructureSection>
 
==Reference==
<ref group="xtra">PMID:019679088</ref><references group="xtra"/>
[[Category: Cyclic-guanylate-specific phosphodiesterase]]
[[Category: Cyclic-guanylate-specific phosphodiesterase]]
[[Category: Pseudomonas aeruginosa pao1]]
[[Category: Pseudomonas aeruginosa pao1]]
[[Category: Bae, N.]]
[[Category: Bae, N]]
[[Category: De, N.]]
[[Category: De, N]]
[[Category: Navarro, M V.]]
[[Category: Navarro, M V]]
[[Category: Sondermann, H.]]
[[Category: Sondermann, H]]
[[Category: Wang, Q.]]
[[Category: Wang, Q]]
[[Category: Biofilm]]
[[Category: Biofilm]]
[[Category: C-di-gmp]]
[[Category: C-di-gmp]]
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