2m2e: Difference between revisions
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{{STRUCTURE_2m2e| PDB=2m2e | SCENE= }} | {{STRUCTURE_2m2e| PDB=2m2e | SCENE= }} | ||
===Solution NMR structure of the SANT domain of human DNAJC2, Northeast structural genomics consortium target HR8254a=== | ===Solution NMR structure of the SANT domain of human DNAJC2, Northeast structural genomics consortium target HR8254a=== | ||
==Function== | |||
[[http://www.uniprot.org/uniprot/DNJC2_HUMAN DNJC2_HUMAN]] Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation. Specifically binds DNA sequence 5'-GTCAAGC-3'.<ref>PMID:16002468</ref> <ref>PMID:15802566</ref> <ref>PMID:21179169</ref> | |||
==About this Structure== | ==About this Structure== | ||
[[2m2e]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M2E OCA]. | [[2m2e]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M2E OCA]. | ||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Arrowsmith, C.]] | [[Category: Arrowsmith, C.]] | ||
Revision as of 08:08, 30 October 2013
Solution NMR structure of the SANT domain of human DNAJC2, Northeast structural genomics consortium target HR8254a
Function
[DNJC2_HUMAN] Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation. Specifically binds DNA sequence 5'-GTCAAGC-3'.[1] [2] [3]
About this Structure
2m2e is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA.
Reference
- ↑ Otto H, Conz C, Maier P, Wolfle T, Suzuki CK, Jeno P, Rucknagel P, Stahl J, Rospert S. The chaperones MPP11 and Hsp70L1 form the mammalian ribosome-associated complex. Proc Natl Acad Sci U S A. 2005 Jul 19;102(29):10064-9. Epub 2005 Jul 7. PMID:16002468 doi:https://dx.doi.org/10.1073/pnas.0504400102
- ↑ Hundley HA, Walter W, Bairstow S, Craig EA. Human Mpp11 J protein: ribosome-tethered molecular chaperones are ubiquitous. Science. 2005 May 13;308(5724):1032-4. Epub 2005 Mar 31. PMID:15802566 doi:https://dx.doi.org/10.1126/science.1109247
- ↑ Richly H, Rocha-Viegas L, Ribeiro JD, Demajo S, Gundem G, Lopez-Bigas N, Nakagawa T, Rospert S, Ito T, Di Croce L. Transcriptional activation of polycomb-repressed genes by ZRF1. Nature. 2010 Dec 23;468(7327):1124-8. doi: 10.1038/nature09574. PMID:21179169 doi:https://dx.doi.org/10.1038/nature09574
