2a68: Difference between revisions

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[[Image:2a68.gif|left|200px]]<br /><applet load="2a68" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2a68.gif|left|200px]]
caption="2a68, resolution 2.50&Aring;" />
 
'''Crystal structure of the T. thermophilus RNA polymerase holoenzyme in complex with antibiotic rifabutin'''<br />
{{Structure
|PDB= 2a68 |SIZE=350|CAPTION= <scene name='initialview01'>2a68</scene>, resolution 2.50&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=RBT:RIFABUTIN'>RBT</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> and <scene name='pdbligand=MG:MAGNESIUM ION'>MG</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/DNA-directed_RNA_polymerase DNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.6 2.7.7.6]
|GENE=
}}
 
'''Crystal structure of the T. thermophilus RNA polymerase holoenzyme in complex with antibiotic rifabutin'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2A68 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus] with <scene name='pdbligand=RBT:'>RBT</scene>, <scene name='pdbligand=ZN:'>ZN</scene> and <scene name='pdbligand=MG:'>MG</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/DNA-directed_RNA_polymerase DNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.6 2.7.7.6] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A68 OCA].  
2A68 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A68 OCA].  


==Reference==
==Reference==
Allosteric modulation of the RNA polymerase catalytic reaction is an essential component of transcription control by rifamycins., Artsimovitch I, Vassylyeva MN, Svetlov D, Svetlov V, Perederina A, Igarashi N, Matsugaki N, Wakatsuki S, Tahirov TH, Vassylyev DG, Cell. 2005 Aug 12;122(3):351-63. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16096056 16096056]
Allosteric modulation of the RNA polymerase catalytic reaction is an essential component of transcription control by rifamycins., Artsimovitch I, Vassylyeva MN, Svetlov D, Svetlov V, Perederina A, Igarashi N, Matsugaki N, Wakatsuki S, Tahirov TH, Vassylyev DG, Cell. 2005 Aug 12;122(3):351-63. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16096056 16096056]
[[Category: DNA-directed RNA polymerase]]
[[Category: DNA-directed RNA polymerase]]
[[Category: Protein complex]]
[[Category: Protein complex]]
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[[Category: rna polymerase holoenzyme]]
[[Category: rna polymerase holoenzyme]]
[[Category: rsgi]]
[[Category: rsgi]]
[[Category: structural genomics]]
[[Category: structural genomic]]
[[Category: transcription regulation]]
[[Category: transcription regulation]]


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