2a7q: Difference between revisions

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[[Image:2a7q.gif|left|200px]]<br /><applet load="2a7q" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2a7q.gif|left|200px]]
caption="2a7q, resolution 2.55&Aring;" />
 
'''Crystal structure of human dCK complexed with clofarabine and ADP'''<br />
{{Structure
|PDB= 2a7q |SIZE=350|CAPTION= <scene name='initialview01'>2a7q</scene>, resolution 2.55&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ADP:ADENOSINE-5'-DIPHOSPHATE'>ADP</scene> and <scene name='pdbligand=CFB:2-CHLORO-9-(2-DEOXY-2-FLUORO-B -D-ARABINOFURANOSYL)-9H-PURIN-6-AMINE'>CFB</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Deoxycytidine_kinase Deoxycytidine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.74 2.7.1.74]
|GENE= DCK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
}}
 
'''Crystal structure of human dCK complexed with clofarabine and ADP'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2A7Q is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=MG:'>MG</scene>, <scene name='pdbligand=ADP:'>ADP</scene> and <scene name='pdbligand=CFB:'>CFB</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Deoxycytidine_kinase Deoxycytidine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.74 2.7.1.74] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A7Q OCA].  
2A7Q is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A7Q OCA].  


==Reference==
==Reference==
The structure of human deoxycytidine kinase in complex with clofarabine reveals key interactions for prodrug activation., Zhang Y, Secrist JA 3rd, Ealick SE, Acta Crystallogr D Biol Crystallogr. 2006 Feb;62(Pt 2):133-9. Epub 2006, Jan 18. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16421443 16421443]
The structure of human deoxycytidine kinase in complex with clofarabine reveals key interactions for prodrug activation., Zhang Y, Secrist JA 3rd, Ealick SE, Acta Crystallogr D Biol Crystallogr. 2006 Feb;62(Pt 2):133-9. Epub 2006, Jan 18. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16421443 16421443]
[[Category: Deoxycytidine kinase]]
[[Category: Deoxycytidine kinase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: CFB]]
[[Category: CFB]]
[[Category: MG]]
[[Category: MG]]
[[Category: alpha/beta parallel beta-sheet of 5 strands]]
[[Category: alpha/beta parallel beta-sheet of 5 strand]]


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