2a97: Difference between revisions

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[[Image:2a97.gif|left|200px]]<br /><applet load="2a97" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2a97.gif|left|200px]]
caption="2a97, resolution 1.80&Aring;" />
 
'''Crystal structure of catalytic domain of Clostridium botulinum neurotoxin serotype F'''<br />
{{Structure
|PDB= 2a97 |SIZE=350|CAPTION= <scene name='initialview01'>2a97</scene>, resolution 1.80&Aring;
|SITE= <scene name='pdbsite=CDA:First+Cd+Binding+Site'>CDA</scene>, <scene name='pdbsite=CDB:Second+Cd+Binding+Site'>CDB</scene>, <scene name='pdbsite=CDC:Third+Cd+Binding+Site'>CDC</scene>, <scene name='pdbsite=CDD:Fourt+Cd+Binding+Site'>CDD</scene>, <scene name='pdbsite=CDE:Fifth+Cd+Binding+Site'>CDE</scene>, <scene name='pdbsite=CDF:Sixth+Cd+Binding+Site'>CDF</scene>, <scene name='pdbsite=ZNA:First+Zn+Binding+Site'>ZNA</scene> and <scene name='pdbsite=ZNB:Second+Zn+Binding+Site'>ZNB</scene>
|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> and <scene name='pdbligand=CD:CADMIUM ION'>CD</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Bontoxilysin Bontoxilysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.69 3.4.24.69]
|GENE= botF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1491 Clostridium botulinum])
}}
 
'''Crystal structure of catalytic domain of Clostridium botulinum neurotoxin serotype F'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2A97 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Clostridium_botulinum Clostridium botulinum] with <scene name='pdbligand=ZN:'>ZN</scene> and <scene name='pdbligand=CD:'>CD</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Bontoxilysin Bontoxilysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.69 3.4.24.69] Known structural/functional Sites: <scene name='pdbsite=CDA:First+Cd+Binding+Site'>CDA</scene>, <scene name='pdbsite=CDB:Second+Cd+Binding+Site'>CDB</scene>, <scene name='pdbsite=CDC:Third+Cd+Binding+Site'>CDC</scene>, <scene name='pdbsite=CDD:Fourt+Cd+Binding+Site'>CDD</scene>, <scene name='pdbsite=CDE:Fifth+Cd+Binding+Site'>CDE</scene>, <scene name='pdbsite=CDF:Sixth+Cd+Binding+Site'>CDF</scene>, <scene name='pdbsite=ZNA:First+Zn+Binding+Site'>ZNA</scene> and <scene name='pdbsite=ZNB:Second+Zn+Binding+Site'>ZNB</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A97 OCA].  
2A97 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Clostridium_botulinum Clostridium botulinum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A97 OCA].  


==Reference==
==Reference==
Structural analysis of botulinum neurotoxin serotype F light chain: implications on substrate binding and inhibitor design., Agarwal R, Binz T, Swaminathan S, Biochemistry. 2005 Sep 6;44(35):11758-65. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16128577 16128577]
Structural analysis of botulinum neurotoxin serotype F light chain: implications on substrate binding and inhibitor design., Agarwal R, Binz T, Swaminathan S, Biochemistry. 2005 Sep 6;44(35):11758-65. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16128577 16128577]
[[Category: Bontoxilysin]]
[[Category: Bontoxilysin]]
[[Category: Clostridium botulinum]]
[[Category: Clostridium botulinum]]
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[[Category: clostridium botulinum neurotoxin serotype f; light chain; catalytic domain; x-ray; crystal structure; zinc endopeptidase]]
[[Category: clostridium botulinum neurotoxin serotype f; light chain; catalytic domain; x-ray; crystal structure; zinc endopeptidase]]


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