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| caption="1jvb, resolution 1.85Å" /> | | caption="1jvb, resolution 1.85Å" /> |
| '''ALCOHOL DEHYDROGENASE FROM THE ARCHAEON SULFOLOBUS SOLFATARICUS'''<br /> | | '''ALCOHOL DEHYDROGENASE FROM THE ARCHAEON SULFOLOBUS SOLFATARICUS'''<br /> |
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| ==Overview==
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| The crystal structure of a medium-chain NAD(H)-dependent alcohol, dehydrogenase (ADH) from an archaeon has been solved by multiwavelength, anomalous diffraction, using a selenomethionine-substituted enzyme. The, protein (SsADH), extracted from the hyperthermophilic organism Sulfolobus, solfataricus, is a homo-tetramer with a crystallographic 222 symmetry., Despite the low level of sequence identity, the overall fold of the, monomer is similar to that of the other homologous ADHs of known, structure. However, a significant difference is the orientation of the, catalytic domain relative to the coenzyme-binding domain that results in a, larger interdomain cleft. At the bottom of this cleft, the catalytic zinc, ion is coordinated tetrahedrally and lacks the zinc-bound water molecule, that is ... [[http://ispc.weizmann.ac.il/pmbin/getpm?12051852 (full description)]]
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| ==About this Structure== | | ==About this Structure== |
| 1JVB is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Sulfolobus_solfataricus Sulfolobus solfataricus]] with ZN as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/Alcohol_dehydrogenase Alcohol dehydrogenase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.1 1.1.1.1]]. Structure known Active Sites: ZNC and ZNS. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1JVB OCA]]. | | 1JVB is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Sulfolobus_solfataricus Sulfolobus solfataricus] with ZN as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Alcohol_dehydrogenase Alcohol dehydrogenase], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.1 1.1.1.1]]. Structure known Active Sites: ZNC and ZNS. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1JVB OCA]]. |
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| ==Reference== | | ==Reference== |
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| [[Category: zinc]] | | [[Category: zinc]] |
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| ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 15:40:58 2007'' | | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 5 12:18:43 2007'' |
