2xz4: Difference between revisions
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[[ | ==CRYSTAL STRUCTURE OF THE LFZ ECTODOMAIN OF THE PEPTIDOGLYCAN RECOGNITION PROTEIN LF== | ||
<StructureSection load='2xz4' size='340' side='right' caption='[[2xz4]], [[Resolution|resolution]] 1.72Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2xz4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XZ4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XZ4 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PG:2-(2-{2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHANOL'>1PG</scene>, <scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> | |||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2xz8|2xz8]]</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xz4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xz4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xz4 RCSB], [http://www.ebi.ac.uk/pdbsum/2xz4 PDBsum]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
The peptidoglycan (PGN)-recognition protein LF (PGRP-LF) is a specific negative regulator of the immune deficiency (Imd) pathway in Drosophila. We determine the crystal structure of the two PGRP domains constituting the ectodomain of PGRP-LF at 1.72 and 1.94 A resolution. The structures show that the LFz and LFw domains do not have a PGN-docking groove that is found in other PGRP domains, and they cannot directly interact with PGN, as confirmed by biochemical-binding assays. By using surface plasmon resonance analysis, we show that the PGRP-LF ectodomain interacts with the PGRP-LCx ectodomain in the absence and presence of tracheal cytotoxin. Our results suggest a mechanism for downregulation of the Imd pathway on the basis of the competition between PRGP-LCa and PGRP-LF to bind to PGRP-LCx. | |||
The Drosophila peptidoglycan-recognition protein LF interacts with peptidoglycan-recognition protein LC to downregulate the Imd pathway.,Basbous N, Coste F, Leone P, Vincentelli R, Royet J, Kellenberger C, Roussel A EMBO Rep. 2011 Apr 1;12(4):327-33. Epub 2011 Mar 4. PMID:21372849<ref>PMID:21372849</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
== | |||
< | |||
[[Category: Drosophila melanogaster]] | [[Category: Drosophila melanogaster]] | ||
[[Category: Basbous, N | [[Category: Basbous, N]] | ||
[[Category: Coste, F | [[Category: Coste, F]] | ||
[[Category: Kellenberger, C | [[Category: Kellenberger, C]] | ||
[[Category: Leone, P | [[Category: Leone, P]] | ||
[[Category: Roussel, A | [[Category: Roussel, A]] | ||
[[Category: Royet, J | [[Category: Royet, J]] | ||
[[Category: Vincentelli, R | [[Category: Vincentelli, R]] | ||
[[Category: Immune system]] | [[Category: Immune system]] | ||
[[Category: Innate immunity]] | [[Category: Innate immunity]] | ||
Revision as of 08:50, 26 November 2014
CRYSTAL STRUCTURE OF THE LFZ ECTODOMAIN OF THE PEPTIDOGLYCAN RECOGNITION PROTEIN LF
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