3g1m: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
{{STRUCTURE_3g1m| PDB=3g1m | SCENE= }} | {{STRUCTURE_3g1m| PDB=3g1m | SCENE= }} | ||
===EthR from Mycobacterium tuberculosis in complex with compound BDM31381=== | ===EthR from Mycobacterium tuberculosis in complex with compound BDM31381=== | ||
{{ABSTRACT_PUBMED_19412174}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/ETHR_MYCTU ETHR_MYCTU]] Involved in the repression of the monooxygenase EthA which is responsible of the formation of the active metabolite of ethionamide (ETH).<ref>PMID:10869356</ref> <ref>PMID:10944230</ref> | |||
==About this Structure== | ==About this Structure== | ||
[[3g1m]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/ | [[3g1m]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G1M OCA]. | ||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID:019412174</ref>< | <ref group="xtra">PMID:019412174</ref><references group="xtra"/><references/> | ||
[[Category: Aumercier, M.]] | [[Category: Aumercier, M.]] | ||
[[Category: Baulard, A R.]] | [[Category: Baulard, A R.]] | ||
Revision as of 13:45, 12 March 2014
EthR from Mycobacterium tuberculosis in complex with compound BDM31381
Template:ABSTRACT PUBMED 19412174
Function
[ETHR_MYCTU] Involved in the repression of the monooxygenase EthA which is responsible of the formation of the active metabolite of ethionamide (ETH).[1] [2]
About this Structure
3g1m is a 1 chain structure with sequence from "bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884. Full crystallographic information is available from OCA.
Reference
- Willand N, Dirie B, Carette X, Bifani P, Singhal A, Desroses M, Leroux F, Willery E, Mathys V, Deprez-Poulain R, Delcroix G, Frenois F, Aumercier M, Locht C, Villeret V, Deprez B, Baulard AR. Synthetic EthR inhibitors boost antituberculous activity of ethionamide. Nat Med. 2009 May;15(5):537-44. Epub 2009 May 3. PMID:19412174 doi:10.1038/nm.1950
- ↑ Baulard AR, Betts JC, Engohang-Ndong J, Quan S, McAdam RA, Brennan PJ, Locht C, Besra GS. Activation of the pro-drug ethionamide is regulated in mycobacteria. J Biol Chem. 2000 Sep 8;275(36):28326-31. PMID:10869356 doi:10.1074/jbc.M003744200
- ↑ DeBarber AE, Mdluli K, Bosman M, Bekker LG, Barry CE 3rd. Ethionamide activation and sensitivity in multidrug-resistant Mycobacterium tuberculosis. Proc Natl Acad Sci U S A. 2000 Aug 15;97(17):9677-82. PMID:10944230
