2acl: Difference between revisions

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[[Image:2acl.gif|left|200px]]<br /><applet load="2acl" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2acl.gif|left|200px]]
caption="2acl, resolution 2.8&Aring;" />
 
'''Liver X-Receptor alpha Ligand Binding Domain with SB313987'''<br />
{{Structure
|PDB= 2acl |SIZE=350|CAPTION= <scene name='initialview01'>2acl</scene>, resolution 2.8&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=L05:1-BENZYL-3-(4-METHOXYPHENYLAMINO)-4-PHENYLPYRROLE-2,5-DIONE'>L05</scene> and <scene name='pdbligand=REA:RETINOIC ACID'>REA</scene>
|ACTIVITY=
|GENE= RXRA, NR2B1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), Nr1h3, Lxra ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])
}}
 
'''Liver X-Receptor alpha Ligand Binding Domain with SB313987'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2ACL is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with <scene name='pdbligand=L05:'>L05</scene> and <scene name='pdbligand=REA:'>REA</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ACL OCA].  
2ACL is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ACL OCA].  


==Reference==
==Reference==
Discovery of substituted maleimides as liver X receptor agonists and determination of a ligand-bound crystal structure., Jaye MC, Krawiec JA, Campobasso N, Smallwood A, Qiu C, Lu Q, Kerrigan JJ, De Los Frailes Alvaro M, Laffitte B, Liu WS, Marino JP Jr, Meyer CR, Nichols JA, Parks DJ, Perez P, Sarov-Blat L, Seepersaud SD, Steplewski KM, Thompson SK, Wang P, Watson MA, Webb CL, Haigh D, Caravella JA, Macphee CH, Willson TM, Collins JL, J Med Chem. 2005 Aug 25;48(17):5419-22. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16107141 16107141]
Discovery of substituted maleimides as liver X receptor agonists and determination of a ligand-bound crystal structure., Jaye MC, Krawiec JA, Campobasso N, Smallwood A, Qiu C, Lu Q, Kerrigan JJ, De Los Frailes Alvaro M, Laffitte B, Liu WS, Marino JP Jr, Meyer CR, Nichols JA, Parks DJ, Perez P, Sarov-Blat L, Seepersaud SD, Steplewski KM, Thompson SK, Wang P, Watson MA, Webb CL, Haigh D, Caravella JA, Macphee CH, Willson TM, Collins JL, J Med Chem. 2005 Aug 25;48(17):5419-22. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16107141 16107141]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: nuclear hormone receptor ligand binding domain transcription factor three layered a-helix fold]]
[[Category: nuclear hormone receptor ligand binding domain transcription factor three layered a-helix fold]]


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