4hcp: Difference between revisions
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{{STRUCTURE_4hcp| PDB=4hcp | SCENE= }} | {{STRUCTURE_4hcp| PDB=4hcp | SCENE= }} | ||
===crystal structure of Burkholderia pseudomallei effector protein chbp in complex with nedd8=== | ===crystal structure of Burkholderia pseudomallei effector protein chbp in complex with nedd8=== | ||
{{ABSTRACT_PUBMED_23175788}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/NEDD8_HUMAN NEDD8_HUMAN]] Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins.<ref>PMID:10318914</ref> <ref>PMID:10597293</ref> <ref>PMID:11953428</ref> | |||
==About this Structure== | ==About this Structure== | ||
[[4hcp]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ | [[4hcp]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Burps Burps] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HCP OCA]. | ||
[[Category: | |||
[[Category: | ==Reference== | ||
<ref group="xtra">PMID:023175788</ref><references group="xtra"/><references/> | |||
[[Category: Burps]] | |||
[[Category: Human]] | |||
[[Category: Shao, F.]] | [[Category: Shao, F.]] | ||
[[Category: Yao, Q.]] | [[Category: Yao, Q.]] | ||
