1lyb: Difference between revisions
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{{STRUCTURE_1lyb| PDB=1lyb | SCENE= }} | {{STRUCTURE_1lyb| PDB=1lyb | SCENE= }} | ||
===CRYSTAL STRUCTURES OF NATIVE AND INHIBITED FORMS OF HUMAN CATHEPSIN D: IMPLICATIONS FOR LYSOSOMAL TARGETING AND DRUG DESIGN=== | |||
{{ABSTRACT_PUBMED_8393577}} | |||
=== | ==Disease== | ||
[[http://www.uniprot.org/uniprot/CATD_HUMAN CATD_HUMAN]] Defects in CTSD are the cause of neuronal ceroid lipofuscinosis type 10 (CLN10) [MIM:[http://omim.org/entry/610127 610127]]; also known as neuronal ceroid lipofuscinosis due to cathepsin D deficiency. A form of neuronal ceroid lipofuscinosis with onset at birth or early childhood. Neuronal ceroid lipofuscinoses are progressive neurodegenerative, lysosomal storage diseases characterized by intracellular accumulation of autofluorescent liposomal material, and clinically by seizures, dementia, visual loss, and/or cerebral atrophy.<ref>PMID:16670177</ref><ref>PMID:16685649</ref><ref>PMID:21990111</ref> | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/CATD_HUMAN CATD_HUMAN]] Acid protease active in intracellular protein breakdown. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease. | |||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID:008393577</ref><references group="xtra"/> | <ref group="xtra">PMID:008393577</ref><references group="xtra"/><references/> | ||
[[Category: Cathepsin D]] | [[Category: Cathepsin D]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
