4dht: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

===Small-molecule inhibitors of 14-3-3 protein-protein interactions from virtual screening===

~~The entry 4dht is ON HOLD~~ ~~until Jul 31 2014~~

==Function==

[[http://www.uniprot.org/uniprot/1433S_HUMAN 1433S_HUMAN]] Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway (By similarity). p53-regulated inhibitor of G2/M progression.

~~Authors~~: ~~Thiel, P~~.~~, Roeglin, L~~., Kohlbacher, O., Ottmann, C.

==About this Structure==

[[4dht]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DHT OCA].

~~Description~~: ~~Small-molecule inhibitors of 14-3-3~~ protein-~~protein interactions from virtual screening~~

[[Category: Homo sapiens]]

[[Category: Kohlbacher, O.]]

[[Category: Ottmann, C.]]

[[Category: Roeglin, L.]]

[[Category: Thiel, P.]]

[[Category: Adapter protein]]

[[Category: Helical protein]]

[[Category: Phosphoprotein binding]]

[[Category: Protein binding-inhibitor complex]]

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4dht|  PDB=4dht  |  SCENE=  }}
+===Small-molecule inhibitors of 14-3-3 protein-protein interactions from virtual screening===
-The entry 4dht is ON HOLD  until Jul 31 2014
+==Function==
+[[http://www.uniprot.org/uniprot/1433S_HUMAN 1433S_HUMAN]] Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway (By similarity).  p53-regulated inhibitor of G2/M progression.
-Authors: Thiel, P., Roeglin, L., Kohlbacher, O., Ottmann, C.
+==About this Structure==
+[[4dht]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DHT OCA].
-Description: Small-molecule inhibitors of 14-3-3 protein-protein interactions from virtual screening
+[[Category: Homo sapiens]]
+[[Category: Kohlbacher, O.]]
+[[Category: Ottmann, C.]]
+[[Category: Roeglin, L.]]
+[[Category: Thiel, P.]]
+[[Category: Adapter protein]]
+[[Category: Helical protein]]
+[[Category: Phosphoprotein binding]]
+[[Category: Protein binding-inhibitor complex]]