4j8s: Difference between revisions
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{{STRUCTURE_4j8s| PDB=4j8s | SCENE= }} | |||
===Crystal structure of human CNOT1 MIF4G domain in complex with a TTP peptide=== | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/CNOT1_HUMAN CNOT1_HUMAN]] Belongs to the CCR4-NOT complex that functions as general transcription regulation complex. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors.<ref>PMID:10637334</ref> <ref>PMID:16778766</ref> [[http://www.uniprot.org/uniprot/TTP_HUMAN TTP_HUMAN]] mRNA-binding protein involved in post-transcriptional regulation of AU-rich element (ARE)-containing mRNAs. Acts by specifically binding ARE-containing mRNAs and promoting their degradation. Plays a key role in the post-transcriptional regulation of tumor necrosis factor (TNF).<ref>PMID:15014438</ref> | |||
==About this Structure== | |||
[[4j8s]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J8S OCA]. | |||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Homo sapiens]] | |||
[[Category: Blackshear, P J.]] | |||
[[Category: Fabian, M R.]] | |||
[[Category: Frank, F.]] | |||
[[Category: Karetnikov, A.]] | |||
[[Category: Lai, W S.]] | |||
[[Category: Nagar, B.]] | |||
[[Category: Rouya, C.]] | |||
[[Category: Siddiqui, N.]] | |||
[[Category: Sonenberg, N.]] | |||
[[Category: Cytosol]] | |||
[[Category: Mif4g]] | |||
[[Category: Protein binding]] | |||
[[Category: Protein-protein interaction]] | |||
[[Category: Ttp]] | |||
Revision as of 07:55, 8 May 2013
Crystal structure of human CNOT1 MIF4G domain in complex with a TTP peptide
Function
[CNOT1_HUMAN] Belongs to the CCR4-NOT complex that functions as general transcription regulation complex. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors.[1] [2] [TTP_HUMAN] mRNA-binding protein involved in post-transcriptional regulation of AU-rich element (ARE)-containing mRNAs. Acts by specifically binding ARE-containing mRNAs and promoting their degradation. Plays a key role in the post-transcriptional regulation of tumor necrosis factor (TNF).[3]
About this Structure
4j8s is a 2 chain structure with sequence from [1] and Homo sapiens. Full crystallographic information is available from OCA.
Reference
- ↑ Albert TK, Lemaire M, van Berkum NL, Gentz R, Collart MA, Timmers HT. Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits. Nucleic Acids Res. 2000 Feb 1;28(3):809-17. PMID:10637334
- ↑ Winkler GS, Mulder KW, Bardwell VJ, Kalkhoven E, Timmers HT. Human Ccr4-Not complex is a ligand-dependent repressor of nuclear receptor-mediated transcription. EMBO J. 2006 Jul 12;25(13):3089-99. Epub 2006 Jun 15. PMID:16778766 doi:7601194
- ↑ Stoecklin G, Stubbs T, Kedersha N, Wax S, Rigby WF, Blackwell TK, Anderson P. MK2-induced tristetraprolin:14-3-3 complexes prevent stress granule association and ARE-mRNA decay. EMBO J. 2004 Mar 24;23(6):1313-24. Epub 2004 Mar 11. PMID:15014438 doi:10.1038/sj.emboj.7600163
