4jb8: Difference between revisions
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{{STRUCTURE_4jb8| PDB=4jb8 | SCENE= }} | |||
===Caspase-7 in Complex with DARPin C7_16=== | |||
{{ABSTRACT_PUBMED_23868333}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/CASP7_HUMAN CASP7_HUMAN]] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Overexpression promotes programmed cell death. | |||
==About this Structure== | |||
[[4jb8]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JB8 OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:023868333</ref><references group="xtra"/><references/> | |||
[[Category: Caspase-7]] | |||
[[Category: Homo sapiens]] | |||
[[Category: Synthetic construct]] | |||
[[Category: Fluetsch, A.]] | |||
[[Category: Gruetter, M G.]] | |||
[[Category: Seeger, M A.]] | |||
[[Category: Complex structure]] | |||
[[Category: Hydrolase-de novo protein complex]] | |||
[[Category: Selected darpin c7_16]] | |||
Revision as of 08:20, 21 August 2013
Caspase-7 in Complex with DARPin C7_16
Template:ABSTRACT PUBMED 23868333
Function
[CASP7_HUMAN] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Overexpression promotes programmed cell death.
About this Structure
4jb8 is a 3 chain structure with sequence from Homo sapiens and Synthetic construct. Full crystallographic information is available from OCA.
Reference
- Seeger MA, Zbinden R, Flutsch A, Gutte PG, Engeler S, Roschitzki-Voser H, Grutter MG. Design, construction, and characterization of a second-generation DARPin library with reduced hydrophobicity. Protein Sci. 2013 Jul 19. doi: 10.1002/pro.2312. PMID:23868333 doi:10.1002/pro.2312
