2an4: Difference between revisions

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[[Image:2an4.gif|left|200px]]<br /><applet load="2an4" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2an4.gif|left|200px]]
caption="2an4, resolution 2.200&Aring;" />
 
'''Structure of PNMT complexed with S-adenosyl-L-homocysteine and the acceptor substrate octopamine'''<br />
{{Structure
|PDB= 2an4 |SIZE=350|CAPTION= <scene name='initialview01'>2an4</scene>, resolution 2.200&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene> and <scene name='pdbligand=OTR:4-(2R-AMINO-1-HYDROXYETHYL)PHENOL'>OTR</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Phenylethanolamine_N-methyltransferase Phenylethanolamine N-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.28 2.1.1.28]
|GENE= PNMT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
}}
 
'''Structure of PNMT complexed with S-adenosyl-L-homocysteine and the acceptor substrate octopamine'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2AN4 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=PO4:'>PO4</scene>, <scene name='pdbligand=SAH:'>SAH</scene> and <scene name='pdbligand=OTR:'>OTR</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Phenylethanolamine_N-methyltransferase Phenylethanolamine N-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.28 2.1.1.28] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AN4 OCA].  
2AN4 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AN4 OCA].  


==Reference==
==Reference==
Mode of binding of methyl acceptor substrates to the adrenaline-synthesizing enzyme phenylethanolamine N-methyltransferase: implications for catalysis., Gee CL, Tyndall JD, Grunewald GL, Wu Q, McLeish MJ, Martin JL, Biochemistry. 2005 Dec 27;44(51):16875-85. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16363801 16363801]
Mode of binding of methyl acceptor substrates to the adrenaline-synthesizing enzyme phenylethanolamine N-methyltransferase: implications for catalysis., Gee CL, Tyndall JD, Grunewald GL, Wu Q, McLeish MJ, Martin JL, Biochemistry. 2005 Dec 27;44(51):16875-85. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16363801 16363801]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Phenylethanolamine N-methyltransferase]]
[[Category: Phenylethanolamine N-methyltransferase]]
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[[Category: substrate structure]]
[[Category: substrate structure]]


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