2aoa: Difference between revisions

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[[Image:2aoa.gif|left|200px]]<br /><applet load="2aoa" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2aoa.gif|left|200px]]
caption="2aoa, resolution 1.99&Aring;" />
 
'''Crystal structures of a high-affinity macrocyclic peptide mimetic in complex with the Grb2 SH2 domain'''<br />
{{Structure
|PDB= 2aoa |SIZE=350|CAPTION= <scene name='initialview01'>2aoa</scene>, resolution 1.99&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=S1S:2-(4-((9S,10S,14S,Z)-18-(2-AMINO-2-OXOETHYL)-9-(CARBOXYMETHYL)-14-(NAPHTHALEN-1-YLMETHYL)-8,17,20-TRIOXO-7,16,19-TRIAZASPIRO[5.14]ICOS-11-EN-10-YL)PHENYL)MALONIC+ACID'>S1S</scene> and <scene name='pdbligand=P33:3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL'>P33</scene>
|ACTIVITY=
|GENE= GRB2, ASH ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
}}
 
'''Crystal structures of a high-affinity macrocyclic peptide mimetic in complex with the Grb2 SH2 domain'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2AOA is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=S1S:'>S1S</scene> and <scene name='pdbligand=P33:'>P33</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AOA OCA].  
2AOA is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AOA OCA].  


==Reference==
==Reference==
Crystal structures of a high-affinity macrocyclic peptide mimetic in complex with the Grb2 SH2 domain., Phan J, Shi ZD, Burke TR Jr, Waugh DS, J Mol Biol. 2005 Oct 14;353(1):104-15. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16165154 16165154]
Crystal structures of a high-affinity macrocyclic peptide mimetic in complex with the Grb2 SH2 domain., Phan J, Shi ZD, Burke TR Jr, Waugh DS, J Mol Biol. 2005 Oct 14;353(1):104-15. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16165154 16165154]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: peptide mimetic]]
[[Category: peptide mimetic]]


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