2aoz: Difference between revisions
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[[Image:2aoz.gif|left|200px]] | [[Image:2aoz.gif|left|200px]] | ||
'''Crystal structure of the myotoxin-II from Atropoides nummifer venom''' | {{Structure | ||
|PDB= 2aoz |SIZE=350|CAPTION= <scene name='initialview01'>2aoz</scene>, resolution 2.08Å | |||
|SITE= | |||
|LIGAND= <scene name='pdbligand=SO4:SULFATE ION'>SO4</scene> | |||
|ACTIVITY= | |||
|GENE= | |||
}} | |||
'''Crystal structure of the myotoxin-II from Atropoides nummifer venom''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
2AOZ is a [ | 2AOZ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Atropoides_nummifer Atropoides nummifer]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AOZ OCA]. | ||
==Reference== | ==Reference== | ||
Structure of myotoxin II, a catalytically inactive Lys49 phospholipase A2 homologue from Atropoides nummifer venom., Murakami MT, Melo CC, Angulo Y, Lomonte B, Arni RK, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 May 1;62(Pt, 5):423-6. Epub 2006 Apr 12. PMID:[http:// | Structure of myotoxin II, a catalytically inactive Lys49 phospholipase A2 homologue from Atropoides nummifer venom., Murakami MT, Melo CC, Angulo Y, Lomonte B, Arni RK, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 May 1;62(Pt, 5):423-6. Epub 2006 Apr 12. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16682766 16682766] | ||
[[Category: Atropoides nummifer]] | [[Category: Atropoides nummifer]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: x-ray diffration]] | [[Category: x-ray diffration]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:52:08 2008'' | ||
Revision as of 13:52, 20 March 2008
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| 2aoz, resolution 2.08Å | |||||||||||||
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| Ligands: | SO4 | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
Crystal structure of the myotoxin-II from Atropoides nummifer venom
Overview
Lys49 snake-venom phospholipase A2 (PLA2) homologues are highly myotoxic proteins which, although lacking catalytic activity, possess the ability to disrupt biological membranes, inducing significant muscle-tissue loss and permanent disability in severely envenomed patients. Since the structural basis for their toxic activity is still only partially understood, the structure of myotoxin II, a monomeric Lys49 PLA2 homologue from Atropoides nummifer, has been determined at 2.08 angstroms resolution and the anion-binding site has been characterized.
About this Structure
2AOZ is a Single protein structure of sequence from Atropoides nummifer. Full crystallographic information is available from OCA.
Reference
Structure of myotoxin II, a catalytically inactive Lys49 phospholipase A2 homologue from Atropoides nummifer venom., Murakami MT, Melo CC, Angulo Y, Lomonte B, Arni RK, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 May 1;62(Pt, 5):423-6. Epub 2006 Apr 12. PMID:16682766
Page seeded by OCA on Thu Mar 20 15:52:08 2008
