Group:MUZIC:Plectin: Difference between revisions

The isoform-1 of the human plectin contains 4,684 amino acids [http://www.uniprot.org/uniprot/Q15149 (uniprot:Q15149)]. Plectin can be divided in three main sections; a central coiled-coil rod domain(exon 31), N and C-terminal globular region and exhibits a dumbbell like structure <ref>PMID:8633055</ref>. C-terminal region (exon 32) is composed of 6 homologous repeating domains, and this region has a role in binding to intermediate filaments such as vimentin and cytokeratin <ref>PMID:3430617</ref>. N-terminal globular region contains actin binding domain comprising two calponin homology (exon 2-8) and plakin domain (exon 9-30).