2aqu: Difference between revisions

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[[Image:2aqu.gif|left|200px]]<br /><applet load="2aqu" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2aqu.gif|left|200px]]
caption="2aqu, resolution 2.00&Aring;" />
 
'''Structure of HIV-1 protease bound to atazanavir'''<br />
{{Structure
|PDB= 2aqu |SIZE=350|CAPTION= <scene name='initialview01'>2aqu</scene>, resolution 2.00&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=DR7:(3S,8S,9S,12S)-3,12-BIS(1,1-DIMETHYLETHYL)-8-HYDROXY-4,11-DIOXO-9-(PHENYLMETHYL)-6-[[4-(2-PYRIDINYL)PHENYL]METHYL]-2,5,6,10,13-PENTAAZATETRADECANEDIOIC ACID DIMETHYL ESTER'>DR7</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/HIV-1_retropepsin HIV-1 retropepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.16 3.4.23.16]
|GENE=
}}
 
'''Structure of HIV-1 protease bound to atazanavir'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2AQU is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1] with <scene name='pdbligand=DR7:'>DR7</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/HIV-1_retropepsin HIV-1 retropepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.16 3.4.23.16] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AQU OCA].  
2AQU is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AQU OCA].  


==Reference==
==Reference==
Analysis of HIV-1 CRF_01 A/E protease inhibitor resistance: structural determinants for maintaining sensitivity and developing resistance to atazanavir., Clemente JC, Coman RM, Thiaville MM, Janka LK, Jeung JA, Nukoolkarn S, Govindasamy L, Agbandje-McKenna M, McKenna R, Leelamanit W, Goodenow MM, Dunn BM, Biochemistry. 2006 May 2;45(17):5468-77. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16634628 16634628]
Analysis of HIV-1 CRF_01 A/E protease inhibitor resistance: structural determinants for maintaining sensitivity and developing resistance to atazanavir., Clemente JC, Coman RM, Thiaville MM, Janka LK, Jeung JA, Nukoolkarn S, Govindasamy L, Agbandje-McKenna M, McKenna R, Leelamanit W, Goodenow MM, Dunn BM, Biochemistry. 2006 May 2;45(17):5468-77. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16634628 16634628]
[[Category: HIV-1 retropepsin]]
[[Category: HIV-1 retropepsin]]
[[Category: Human immunodeficiency virus 1]]
[[Category: Human immunodeficiency virus 1]]
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[[Category: Thiaville, M M.]]
[[Category: Thiaville, M M.]]
[[Category: DR7]]
[[Category: DR7]]
[[Category: aids]]
[[Category: aid]]
[[Category: aspartyl protease]]
[[Category: aspartyl protease]]
[[Category: hydrolase]]
[[Category: hydrolase]]


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