4is1: Difference between revisions
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==Crystal structure of ZNF217 bound to DNA== | |||
<StructureSection load='4is1' size='340' side='right' caption='[[4is1]], [[Resolution|resolution]] 2.10Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4is1]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IS1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IS1 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4f2j|4f2j]]</td></tr> | |||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ZNF217, ZABC1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | |||
== | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4is1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4is1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4is1 RCSB], [http://www.ebi.ac.uk/pdbsum/4is1 PDBsum]</span></td></tr> | ||
[[4is1]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IS1 OCA]. | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/ZN217_HUMAN ZN217_HUMAN]] Binds to the promoters of target genes and functions as repressor. Promotes cell proliferation and antagonizes cell death. Promotes phosphorylation of AKT1 at 'Ser-473'.<ref>PMID:16203743</ref> <ref>PMID:17259635</ref> <ref>PMID:18625718</ref> <ref>PMID:16940172</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Guss, J M | [[Category: Guss, J M]] | ||
[[Category: Jacques, D A | [[Category: Jacques, D A]] | ||
[[Category: Mackay, J P | [[Category: Mackay, J P]] | ||
[[Category: Vandevenne, M S | [[Category: Vandevenne, M S]] | ||
[[Category: Metal binding protein-dna complex]] | [[Category: Metal binding protein-dna complex]] | ||
[[Category: Transcription factor]] | [[Category: Transcription factor]] | ||
[[Category: Zinc finger]] | [[Category: Zinc finger]] | ||
