2m50: Difference between revisions

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'''Unreleased structure'''
{{STRUCTURE_2m50|  PDB=2m50  |  SCENE=  }}
===Analysis of the structural and molecular basis of voltage-sensitive sodium channel inhibition by the spider toxin, Huwentoxin-IV (-TRTX-Hh2a).===


The entry 2m50 is ON HOLD until Paper Publication
==Function==
[[http://www.uniprot.org/uniprot/TXH4_HAPSC TXH4_HAPSC]] This lethal neurotoxin acts selectively on tetrodotoxin-sensitive (TTX-S) voltage-gated sodium channels (Nav), with an IC(50) of 30 nM in rat DRG neurons. Preferentially inhibits neuronal voltage-gated sodium channel subtype hNav1.7/SCN9A (IC(50) is 26 nM), rNav1.2/SCN2A (IC(50) is 150 nM), and rNav1.3/SCN3A (IC(50) is 338 nM), compared with muscle subtypes rNav1.4/SCN4A and hNav1.5/SCN5A (IC(50) is > 10 uM). Inhibits activation of sodium channel by trapping the voltage sensor of domain II of the site 4 in the inward, closed configuration.<ref>PMID:12228241</ref> <ref>PMID:18628201</ref>  


Authors: Gibbs, A., Minassian, N., Flinspach, M., Wickenden, A.
==About this Structure==
[[2m50]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Haplopelma_schmidti Haplopelma schmidti]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M50 OCA].  


Description: Analysis of the structural and molecular basis of voltage-sensitive sodium channel inhibition by the spider toxin, Huwentoxin-IV (-TRTX-Hh2a).
==Reference==
<references group="xtra"/><references/>
[[Category: Haplopelma schmidti]]
[[Category: Flinspach, M.]]
[[Category: Gibbs, A.]]
[[Category: Minassian, N.]]
[[Category: Wickenden, A.]]
[[Category: Toxin]]
[[Category: Venom toxin]]
Retrieved from "https://proteopedia.org/2m50"