4b8e: Difference between revisions

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-'''Unreleased structure'''
+{{STRUCTURE_4b8e|  PDB=4b8e  |  SCENE=  }}
+===PRY-SPRY domain of Trim25===
-The entry 4b8e is ON HOLD  until Paper Publication
+==Function==
+[[http://www.uniprot.org/uniprot/TRI25_MOUSE TRI25_MOUSE]] Functions as an ubiquitin E3 ligase and as an ISG15 E3 ligase. Involved in innate immune defense against viruses by mediating ubiquitination of DDX58. Mediates 'Lys-63'-linked polyubiquitination of the DDX58 N-terminal CARD-like region which is crucial for triggering the cytosolic signal transduction that leads to the production of interferons in response to viral infection. Promotes ISGylation of 14-3-3 sigma (SFN), an adapter protein implicated in the regulation of a large spectrum signaling pathway. Mediates estrogen action in various target organs (By similarity).
-Authors: Kershaw, N.J., D'Cruz, A.A., Nicola, N.A., Nicholson, S.E., Babon, J.J.
+==About this Structure==
+[[4b8e]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B8E OCA].
-Description: PRY-SPRY domain of Trim25
+[[Category: Mus musculus]]
+[[Category: Babon, J J.]]
+[[Category: Cruz, A A.D.]]
+[[Category: Kershaw, N J.]]
+[[Category: Nicholson, S E.]]
+[[Category: Nicola, N A.]]
+[[Category: Ligase]]

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