4dkk: Difference between revisions
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'' | {{STRUCTURE_4dkk| PDB=4dkk | SCENE= }} | ||
===The X-ray Crystal Structure of the Human STAU1 SSM-'RBD'5 Domain-Swapped Dimer=== | |||
{{ABSTRACT_PUBMED_23524536}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/STAU1_HUMAN STAU1_HUMAN]] Binds double-stranded RNA (regardless of the sequence) and tubulin. May play a role in specific positioning of mRNAs at given sites in the cell by cross-linking cytoskeletal and RNA components, and in stimulating their translation at the site. | |||
==About this Structure== | |||
[[4dkk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DKK OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:023524536</ref><references group="xtra"/><references/> | |||
[[Category: Homo sapiens]] | |||
[[Category: Gleghorn, M L.]] | |||
[[Category: Beta sheet]] | |||
[[Category: Dimerization]] | |||
[[Category: Protein binding]] | |||
[[Category: Rbd]] | |||
[[Category: Rna binding protein]] | |||
[[Category: Swapping-motif]] | |||
Revision as of 15:05, 19 June 2013
The X-ray Crystal Structure of the Human STAU1 SSM-'RBD'5 Domain-Swapped Dimer
Template:ABSTRACT PUBMED 23524536
Function
[STAU1_HUMAN] Binds double-stranded RNA (regardless of the sequence) and tubulin. May play a role in specific positioning of mRNAs at given sites in the cell by cross-linking cytoskeletal and RNA components, and in stimulating their translation at the site.
About this Structure
4dkk is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Gleghorn ML, Gong C, Kielkopf CL, Maquat LE. Staufen1 dimerizes through a conserved motif and a degenerate dsRNA-binding domain to promote mRNA decay. Nat Struct Mol Biol. 2013 Apr;20(4):515-24. doi: 10.1038/nsmb.2528. Epub 2013 Mar, 24. PMID:23524536 doi:10.1038/nsmb.2528
