4hva: Difference between revisions
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{{STRUCTURE_4hva| PDB=4hva | SCENE= }} | |||
===Mechanistic and Structural Understanding of Uncompetitive Inhibitors of Caspase-6=== | |||
{{ABSTRACT_PUBMED_23227217}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/CASP6_HUMAN CASP6_HUMAN]] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death. | |||
==About this Structure== | |||
[[4hva]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HVA OCA]. | |||
[[Category: Caspase-6]] | |||
[[Category: Homo sapiens]] | |||
[[Category: Murray, J M.]] | |||
[[Category: Steffek, M.]] | |||
[[Category: Active]] | |||
[[Category: Caspase]] | |||
[[Category: Caspase-6]] | |||
[[Category: Hydrolase-hydrolase inhibitor complex]] | |||
[[Category: Protease]] | |||
[[Category: Ternary complex]] | |||
[[Category: Uncompetitive inhibition]] | |||
[[Category: Veid]] | |||