4j8r: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

===Structure of an octapeptide repeat of the prion protein bound to the POM2 Fab antibody fragment===

~~The entry 4j8r is ON HOLD until Paper Publication~~

==Disease==

[[http://www.uniprot.org/uniprot/PRIO_MOUSE PRIO_MOUSE]] Note=Found in high quantity in the brain of humans and animals infected with degenerative neurological diseases such as kuru, Creutzfeldt-Jakob disease (CJD), Gerstmann-Straussler syndrome (GSS), scrapie, bovine spongiform encephalopathy (BSE), transmissible mink encephalopathy (TME), etc.

~~Authors~~: ~~Swayampakula, M~~.~~, Baral, P~~.K.~~, Kav, N~~.N.V.~~, Aguzzi, A~~.~~, James, M.N.G~~.

==Function==

[[http://www.uniprot.org/uniprot/PRIO_MOUSE PRIO_MOUSE]] May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro) (By similarity). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains.<ref>PMID:12732622</ref> <ref>PMID:16492732</ref> <ref>PMID:19242475</ref> <ref>PMID:19568430</ref>

~~Description~~: ~~Structure of an octapeptide repeat of the~~ prion protein ~~bound to the POM2 Fab antibody fragment~~

==About this Structure==

[[4j8r]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J8R OCA].

==Reference==

[[Category: Mus musculus]]

[[Category: Aguzzi, A.]]

[[Category: Baral, P K.]]

[[Category: James, M N.G.]]

[[Category: Kav, N N.V.]]

[[Category: Swayampakula, M.]]

[[Category: Antibody]]

[[Category: Fab]]

[[Category: Immune system]]

[[Category: Immunoglobulin fold]]

[[Category: Mouse prion protein]]

[[Category: Octapeptide repeat]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4j8r|  PDB=4j8r  |  SCENE=  }}
+===Structure of an octapeptide repeat of the prion protein bound to the POM2 Fab antibody fragment===
+{{ABSTRACT_PUBMED_23629842}}
-The entry 4j8r is ON HOLD  until Paper Publication
+==Disease==
+[[http://www.uniprot.org/uniprot/PRIO_MOUSE PRIO_MOUSE]] Note=Found in high quantity in the brain of humans and animals infected with degenerative neurological diseases such as kuru, Creutzfeldt-Jakob disease (CJD), Gerstmann-Straussler syndrome (GSS), scrapie, bovine spongiform encephalopathy (BSE), transmissible mink encephalopathy (TME), etc.
-Authors: Swayampakula, M., Baral, P.K., Kav, N.N.V., Aguzzi, A., James, M.N.G.
+==Function==
+[[http://www.uniprot.org/uniprot/PRIO_MOUSE PRIO_MOUSE]] May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro) (By similarity). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains.<ref>PMID:12732622</ref> <ref>PMID:16492732</ref> <ref>PMID:19242475</ref> <ref>PMID:19568430</ref>
-Description: Structure of an octapeptide repeat of the prion protein bound to the POM2 Fab antibody fragment
+==About this Structure==
+[[4j8r]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J8R OCA].
+==Reference==
+<ref group="xtra">PMID:023629842</ref><references group="xtra"/><references/>
+[[Category: Mus musculus]]
+[[Category: Aguzzi, A.]]
+[[Category: Baral, P K.]]
+[[Category: James, M N.G.]]
+[[Category: Kav, N N.V.]]
+[[Category: Swayampakula, M.]]
+[[Category: Antibody]]
+[[Category: Fab]]
+[[Category: Immune system]]
+[[Category: Immunoglobulin fold]]
+[[Category: Mouse prion protein]]
+[[Category: Octapeptide repeat]]