4jal: Difference between revisions
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{{STRUCTURE_4jal| PDB=4jal | SCENE= }} | |||
===Crystal structure of tRNA (Um34/Cm34) methyltransferase TrmL from Escherichia coli with SAH=== | |||
{{ABSTRACT_PUBMED_23804755}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/TRML_ECOLI TRML_ECOLI]] Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S-adenosyl-L-methionine to the 2'-OH of the wobble nucleotide. Recognition of the target requires a pyridine at position 34 and N(6)-(isopentenyl)-2-methylthioadenosine at position 37.<ref>PMID:20855540</ref> | |||
==About this Structure== | |||
[[4jal]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_k-12 Escherichia coli k-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JAL OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:023804755</ref><references group="xtra"/><references/> | |||
[[Category: Escherichia coli k-12]] | |||
[[Category: Liu, R J.]] | |||
[[Category: Wang, E D.]] | |||
[[Category: Zhou, M.]] | |||
[[Category: Deep trefoil knot]] | |||
[[Category: Methylation]] | |||
[[Category: Methyltransferase]] | |||
[[Category: Sam binding]] | |||
[[Category: Spout]] | |||
[[Category: Transferase]] | |||
[[Category: Trml]] | |||
[[Category: Trna modification]] | |||
Revision as of 05:20, 1 August 2013
Crystal structure of tRNA (Um34/Cm34) methyltransferase TrmL from Escherichia coli with SAH
Template:ABSTRACT PUBMED 23804755
Function
[TRML_ECOLI] Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S-adenosyl-L-methionine to the 2'-OH of the wobble nucleotide. Recognition of the target requires a pyridine at position 34 and N(6)-(isopentenyl)-2-methylthioadenosine at position 37.[1]
About this Structure
4jal is a 2 chain structure with sequence from Escherichia coli k-12. Full crystallographic information is available from OCA.
Reference
- Liu RJ, Zhou M, Fang ZP, Wang M, Zhou XL, Wang ED. The tRNA recognition mechanism of the minimalist SPOUT methyltransferase, TrmL. Nucleic Acids Res. 2013 Jun 26. PMID:23804755 doi:10.1093/nar/gkt568
- ↑ Benitez-Paez A, Villarroya M, Douthwaite S, Gabaldon T, Armengod ME. YibK is the 2'-O-methyltransferase TrmL that modifies the wobble nucleotide in Escherichia coli tRNA(Leu) isoacceptors. RNA. 2010 Nov;16(11):2131-43. doi: 10.1261/rna.2245910. Epub 2010 Sep 20. PMID:20855540 doi:10.1261/rna.2245910
