4jbj: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
{{STRUCTURE_4jbj| PDB=4jbj | SCENE= }} | |||
===Structural mimicry for functional antagonism=== | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/IFI2_MOUSE IFI2_MOUSE]] Inhibits the transcriptional activity of several transcription factors, including NF-kappa-B p50 and p65, FOS, JUN, E2F1, E2F4, MYOD1 and myogenin. Has anti-apoptotic effects due to inhibition of the transcriptional activity of p53. Binds dsDNA in the cytosol. Is involved in innate immune response and has anti-inflammatory activity. Inhibits caspase activation in response to cytosolic DNA and may inhibit the activation of the AIM2 inflammasome, probably via association with AIM2.<ref>PMID:16670293</ref> <ref>PMID:19131592</ref> | |||
==About this Structure== | |||
[[4jbj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JBJ OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:023567559</ref><references group="xtra"/><references/> | |||
[[Category: Mus musculus]] | |||
[[Category: Cheng, G.]] | |||
[[Category: Ding, W.]] | |||
[[Category: Hung, L W.]] | |||
[[Category: Liu, Z J.]] | |||
[[Category: Ma, F.]] | |||
[[Category: Ni, X.]] | |||
[[Category: Ru, H.]] | |||
[[Category: Shaw, N.]] | |||
[[Category: Zhao, L.]] | |||
[[Category: Dna binding protein]] | |||
[[Category: Ds dna]] | |||
[[Category: Ob fold]] | |||
Revision as of 09:55, 30 June 2013
Structural mimicry for functional antagonism
Function
[IFI2_MOUSE] Inhibits the transcriptional activity of several transcription factors, including NF-kappa-B p50 and p65, FOS, JUN, E2F1, E2F4, MYOD1 and myogenin. Has anti-apoptotic effects due to inhibition of the transcriptional activity of p53. Binds dsDNA in the cytosol. Is involved in innate immune response and has anti-inflammatory activity. Inhibits caspase activation in response to cytosolic DNA and may inhibit the activation of the AIM2 inflammasome, probably via association with AIM2.[1] [2]
About this Structure
4jbj is a 2 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
- Ru H, Ni X, Zhao L, Crowley C, Ding W, Hung LW, Shaw N, Cheng G, Liu ZJ. Structural basis for termination of AIM2-mediated signaling by p202. Cell Res. 2013 Jun;23(6):855-8. doi: 10.1038/cr.2013.52. Epub 2013 Apr 9. PMID:23567559 doi:10.1038/cr.2013.52
- ↑ Xin H, D'Souza S, Jorgensen TN, Vaughan AT, Lengyel P, Kotzin BL, Choubey D. Increased expression of Ifi202, an IFN-activatable gene, in B6.Nba2 lupus susceptible mice inhibits p53-mediated apoptosis. J Immunol. 2006 May 15;176(10):5863-70. PMID:16670293
- ↑ Roberts TL, Idris A, Dunn JA, Kelly GM, Burnton CM, Hodgson S, Hardy LL, Garceau V, Sweet MJ, Ross IL, Hume DA, Stacey KJ. HIN-200 proteins regulate caspase activation in response to foreign cytoplasmic DNA. Science. 2009 Feb 20;323(5917):1057-60. doi: 10.1126/science.1169841. Epub 2009, Jan 8. PMID:19131592 doi:10.1126/science.1169841
