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[[Image:4esp.jpg|left|200px]]
==Crystal Structure of Peanut Allergen Ara h 5==
<StructureSection load='4esp' size='340' side='right' caption='[[4esp]], [[Resolution|resolution]] 1.10&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4esp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Arachis_hypogaea Arachis hypogaea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ESP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ESP FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">profilin ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3818 Arachis hypogaea])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4esp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4esp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4esp RCSB], [http://www.ebi.ac.uk/pdbsum/4esp PDBsum]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Profilins from numerous species are known to be allergens, including food allergens, such as peanut ( Arachis hypogaea ) allergen Ara h 5, and pollen allergens, such as birch allergen Bet v 2. Patients with pollen allergy can also cross-react to peanut. Structural characterization of allergens will allow a better understanding of the allergenicity of food allergens and their cross-reactivities. The three-dimensional structures of most known food allergens remain to be elucidated. Here, we report the first crystallographic study of a food allergen in the profilin family. The structure of peanut allergen Ara h 5 was determined, and the resolution of the final refined structure was 1.1 A. Structure alignment revealed that Ara h 5 is more similar to Bet v 2 than to Hev b 8, although sequence alignment suggested that Ara h 5 is more closely related to Hev b 8 than to Bet v 2, indicating that homology-model-based prediction of immunoglobulin E epitopes needs to be interpreted with caution.


{{STRUCTURE_4esp|  PDB=4esp  |  SCENE=  }}
Crystal Structure of Peanut ( Arachis hypogaea ) Allergen Ara h 5.,Wang Y, Fu TJ, Howard A, Kothary MH, McHugh TH, Zhang Y J Agric Food Chem. 2013 Feb 20;61(7):1573-8. doi: 10.1021/jf303861p. Epub 2013, Feb 11. PMID:23350842<ref>PMID:23350842</ref>


===Crystal Structure of Peanut Allergen Ara h 5===
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 
</div>
{{ABSTRACT_PUBMED_23350842}}
== References ==
 
<references/>
==About this Structure==
__TOC__
[[4esp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Arachis_hypogaea Arachis hypogaea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ESP OCA].
</StructureSection>
[[Category: Arachis hypogaea]]
[[Category: Arachis hypogaea]]
[[Category: Wang, Y.]]
[[Category: Wang, Y]]
[[Category: Zhang, Y Z.]]
[[Category: Zhang, Y Z]]
[[Category: Allergen]]
[[Category: Allergen]]
[[Category: Allergy]]
[[Category: Allergy]]
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