2aw1: Difference between revisions

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[[Image:2aw1.gif|left|200px]]<br /><applet load="2aw1" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2aw1.gif|left|200px]]
caption="2aw1, resolution 1.46&Aring;" />
 
'''Carbonic anhydrase inhibitors: Valdecoxib binds to a different active site region of the human isoform II as compared to the structurally related cyclooxygenase II "selective" inhibitor Celecoxib'''<br />
{{Structure
|PDB= 2aw1 |SIZE=350|CAPTION= <scene name='initialview01'>2aw1</scene>, resolution 1.46&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>, <scene name='pdbligand=HGB:4-(HYDROXYMERCURY)BENZOIC+ACID'>HGB</scene>, <scene name='pdbligand=COX:4-(5-METHYL-3-PHENYLISOXAZOL-4-YL)BENZENESULFONAMIDE'>COX</scene> and <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1]
|GENE=
}}
 
'''Carbonic anhydrase inhibitors: Valdecoxib binds to a different active site region of the human isoform II as compared to the structurally related cyclooxygenase II "selective" inhibitor Celecoxib'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2AW1 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=ZN:'>ZN</scene>, <scene name='pdbligand=HGB:'>HGB</scene>, <scene name='pdbligand=COX:'>COX</scene> and <scene name='pdbligand=GOL:'>GOL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AW1 OCA].  
2AW1 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AW1 OCA].  


==Reference==
==Reference==
Carbonic anhydrase inhibitors: Valdecoxib binds to a different active site region of the human isoform II as compared to the structurally related cyclooxygenase II "selective" inhibitor celecoxib., Di Fiore A, Pedone C, D'Ambrosio K, Scozzafava A, De Simone G, Supuran CT, Bioorg Med Chem Lett. 2006 Jan 15;16(2):437-42. Epub 2005 Nov 14. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16290146 16290146]
Carbonic anhydrase inhibitors: Valdecoxib binds to a different active site region of the human isoform II as compared to the structurally related cyclooxygenase II "selective" inhibitor celecoxib., Di Fiore A, Pedone C, D'Ambrosio K, Scozzafava A, De Simone G, Supuran CT, Bioorg Med Chem Lett. 2006 Jan 15;16(2):437-42. Epub 2005 Nov 14. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16290146 16290146]
[[Category: Carbonate dehydratase]]
[[Category: Carbonate dehydratase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: protein-inhibitor complex]]
[[Category: protein-inhibitor complex]]


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