3zp5: Difference between revisions
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==Crystal structure of the DNA binding ETS domain of the human protein FEV in complex with DNA== | |||
<StructureSection load='3zp5' size='340' side='right' caption='[[3zp5]], [[Resolution|resolution]] 2.00Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3zp5]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZP5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZP5 FirstGlance]. <br> | |||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zp5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zp5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zp5 RCSB], [http://www.ebi.ac.uk/pdbsum/3zp5 PDBsum]</span></td></tr> | |||
</table> | |||
== Disease == | |||
== | [[http://www.uniprot.org/uniprot/FEV_HUMAN FEV_HUMAN]] Disease susceptibility may be associated with variations affecting the gene represented in this entry. A chromosomal aberration involving FEV is found in Ewing tumors. Translocation t(2;21;22)(q23;q22;q12) that forms a EWSR1-FEV fusion protein with a potential oncogenic activity. | ||
[[3zp5]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZP5 OCA]. | == Function == | ||
[[http://www.uniprot.org/uniprot/FEV_HUMAN FEV_HUMAN]] Functions as a transcriptional regulator. According to PubMed:12761502, it functions as a transcriptional repressor. Functions in the differentiation and the maintenance of the central serotonergic neurons. May play a role in cell growth.<ref>PMID:12761502</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Allerston, C K | [[Category: Allerston, C K]] | ||
[[Category: Arrowsmith, C H | [[Category: Arrowsmith, C H]] | ||
[[Category: Burgess-Brown, N | [[Category: Burgess-Brown, N]] | ||
[[Category: Cooper, C D.O | [[Category: Cooper, C D.O]] | ||
[[Category: Delft, F von | [[Category: Delft, F von]] | ||
[[Category: Edwards, A | [[Category: Edwards, A]] | ||
[[Category: Gileadi, O | [[Category: Gileadi, O]] | ||
[[Category: Krojer, T | [[Category: Krojer, T]] | ||
[[Category: Newman, J A | [[Category: Newman, J A]] | ||
[[Category: Shrestha, L | [[Category: Shrestha, L]] | ||
[[Category: Vollmar, M | [[Category: Vollmar, M]] | ||
[[Category: Transcription-dna complex]] | [[Category: Transcription-dna complex]] | ||
Revision as of 16:06, 9 December 2014
Crystal structure of the DNA binding ETS domain of the human protein FEV in complex with DNA
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