4fgt: Difference between revisions

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[[~~Image~~:~~4fgt~~.~~jpg~~|~~left~~|~~200px~~]]

==Allosteric peptidic inhibitor of human thymidylate synthase that stabilizes inactive conformation of the enzyme.==

== Structural highlights ==

<table><tr><td colspan='2'>[[4fgt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FGT OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FGT FirstGlance].

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>

<tr id='NonStdRes'><td class="sblockLbl">[[Non-Standard_Residue|NonStd Res:]]</td><td class="sblockDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene></td></tr>

<tr id='related'><td class="sblockLbl">[[Related_structure|Related:]]</td><td class="sblockDat">[[3n5e|3n5e]], [[3egy|3egy]]</td></tr>

<tr id='gene'><td class="sblockLbl">[[Gene|Gene:]]</td><td class="sblockDat">TYMS, TS, OK/SW-cl.29 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>

<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/Thymidylate_synthase Thymidylate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.45 2.1.1.45] </td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fgt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fgt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4fgt RCSB], [http://www.ebi.ac.uk/pdbsum/4fgt PDBsum]</td></tr>

</table>

~~{{STRUCTURE_4fgt| PDB~~=~~4fgt | SCENE= }}~~

==See Also==

*[[Thymidylate synthase|Thymidylate synthase]]

~~===Allosteric peptidic inhibitor of human thymidylate synthase that stabilizes inactive conformation of the enzyme.~~===

__TOC__

</StructureSection>

~~==About this Structure==~~

[[~~4fgt~~]] ~~is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin~~/~~ocashort?id=4FGT OCA].~~

[[Category: Homo sapiens]]

[[Category: Thymidylate synthase]]

[[Category: Costi, M P.]]

[[Category: Costi, M P]]

[[Category: Finer-Moore, J.]]

[[Category: Finer-Moore, J]]

[[Category: Stroud, R M.]]

[[Category: Stroud, R M]]

[[Category: Tochowicz, A.]]

[[Category: Tochowicz, A]]

[[Category: Dimer]]

[[Category: Hts complex with peptidic inhibitor]]

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@@ Line 1: / Line 1: @@
-[[Image:4fgt.jpg|left|200px]]
+==Allosteric peptidic inhibitor of human thymidylate synthase that stabilizes inactive conformation of the enzyme.==
+<StructureSection load='4fgt' size='340' side='right' caption='[[4fgt]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4fgt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FGT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FGT FirstGlance]. <br>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene></td></tr>
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3n5e|3n5e]], [[3egy|3egy]]</td></tr>
+<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TYMS, TS, OK/SW-cl.29 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thymidylate_synthase Thymidylate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.45 2.1.1.45] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fgt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fgt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4fgt RCSB], [http://www.ebi.ac.uk/pdbsum/4fgt PDBsum]</span></td></tr>
+</table>
-{{STRUCTURE_4fgt|  PDB=4fgt  |  SCENE=  }}
+==See Also==
+*[[Thymidylate synthase|Thymidylate synthase]]
-===Allosteric peptidic inhibitor of human thymidylate synthase that stabilizes inactive conformation of the enzyme.===
+__TOC__
+</StructureSection>
-==About this Structure==
-[[4fgt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FGT OCA].
 [[Category: Homo sapiens]]
 [[Category: Thymidylate synthase]]
-[[Category: Costi, M P.]]
+[[Category: Costi, M P]]
-[[Category: Finer-Moore, J.]]
+[[Category: Finer-Moore, J]]
-[[Category: Stroud, R M.]]
+[[Category: Stroud, R M]]
-[[Category: Tochowicz, A.]]
+[[Category: Tochowicz, A]]
 [[Category: Dimer]]
 [[Category: Hts complex with peptidic inhibitor]]