4i0h: Difference between revisions
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[[ | ==SPR and structural analysis yield insight towards mechanism of inhibition of BACE inhibitors.== | ||
<StructureSection load='4i0h' size='340' side='right' caption='[[4i0h]], [[Resolution|resolution]] 2.20Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4i0h]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I0H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4I0H FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1BL:(2R)-5-{[(2S,3R)-4-{[1-(3-TERT-BUTYLPHENYL)CYCLOHEXYL]AMINO}-1-(3,5-DIFLUOROPHENYL)-3-HYDROXYBUTAN-2-YL]AMINO}-2-HYDROXY-5-OXOPENTANOIC+ACID'>1BL</scene></td></tr> | |||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4i0j|4i0j]], [[4i0i|4i0i]]</td></tr> | |||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BACE1, BACE, KIAA1149 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | |||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4i0h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4i0h OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4i0h RCSB], [http://www.ebi.ac.uk/pdbsum/4i0h PDBsum]</span></td></tr> | |||
</table> | |||
==See Also== | |||
*[[Beta secretase|Beta secretase]] | |||
__TOC__ | |||
</StructureSection> | |||
== | |||
[[ | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Memapsin 2]] | [[Category: Memapsin 2]] | ||
[[Category: Brecht, E | [[Category: Brecht, E]] | ||
[[Category: Yao, N | [[Category: Yao, N]] | ||
[[Category: Asp protease]] | [[Category: Asp protease]] | ||
[[Category: Bace]] | [[Category: Bace]] | ||
[[Category: Hydrolase-hydrolase inhibitor complex]] | [[Category: Hydrolase-hydrolase inhibitor complex]] | ||
[[Category: Hydrolysis]] | [[Category: Hydrolysis]] | ||
Revision as of 17:00, 10 December 2014
SPR and structural analysis yield insight towards mechanism of inhibition of BACE inhibitors.
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